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- W2460647586 abstract "Acute myocardial infarction (MI) is a severe ischemic disease responsible for heart failure and sudden death. Inflammatory cells orchestrate postischemic cardiac remodeling after MI. Studies using mice with defective mast/stem cell growth factor receptor c-Kit have suggested key roles for mast cells (MCs) in postischemic cardiac remodeling. Because c-Kit mutations affect multiple cell types of both immune and nonimmune origin, we addressed the impact of MCs on cardiac function after MI, using the c-Kit–independent MC-deficient (Cpa3Cre/+) mice. In response to MI, MC progenitors originated primarily from white adipose tissue, infiltrated the heart, and differentiated into mature MCs. MC deficiency led to reduced postischemic cardiac function and depressed cardiomyocyte contractility caused by myofilament Ca2+ desensitization. This effect correlated with increased protein kinase A (PKA) activity and hyperphosphorylation of its targets, troponin I and myosin-binding protein C. MC-specific tryptase was identified to regulate PKA activity in cardiomyocytes via protease-activated receptor 2 proteolysis. This work reveals a novel function for cardiac MCs modulating cardiomyocyte contractility via alteration of PKA-regulated force–Ca2+ interactions in response to MI. Identification of this MC-cardiomyocyte cross-talk provides new insights on the cellular and molecular mechanisms regulating the cardiac contractile machinery and a novel platform for therapeutically addressable regulators." @default.
- W2460647586 created "2016-07-22" @default.
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- W2460647586 date "2016-06-27" @default.
- W2460647586 modified "2023-10-16" @default.
- W2460647586 title "Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction" @default.
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- W2460647586 cites W1631782483 @default.
- W2460647586 cites W1636878974 @default.
- W2460647586 cites W1671108142 @default.
- W2460647586 cites W1839825739 @default.
- W2460647586 cites W1916767456 @default.
- W2460647586 cites W1939825543 @default.
- W2460647586 cites W1963543751 @default.
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- W2460647586 cites W1966871724 @default.
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- W2460647586 cites W1979129701 @default.
- W2460647586 cites W1982640865 @default.
- W2460647586 cites W1985345188 @default.
- W2460647586 cites W1985761935 @default.
- W2460647586 cites W1986627484 @default.
- W2460647586 cites W1991215694 @default.
- W2460647586 cites W1992324970 @default.
- W2460647586 cites W1994634350 @default.
- W2460647586 cites W1998821679 @default.
- W2460647586 cites W1999031953 @default.
- W2460647586 cites W1999302986 @default.
- W2460647586 cites W2007766703 @default.
- W2460647586 cites W2009953198 @default.
- W2460647586 cites W2010230481 @default.
- W2460647586 cites W2011238768 @default.
- W2460647586 cites W2012664798 @default.
- W2460647586 cites W2013302784 @default.
- W2460647586 cites W2014618422 @default.
- W2460647586 cites W2019301043 @default.
- W2460647586 cites W2021655720 @default.
- W2460647586 cites W2022178125 @default.
- W2460647586 cites W2023328878 @default.
- W2460647586 cites W2024400309 @default.
- W2460647586 cites W2024852158 @default.
- W2460647586 cites W2027759264 @default.
- W2460647586 cites W2028988446 @default.
- W2460647586 cites W2029337152 @default.
- W2460647586 cites W2030000931 @default.
- W2460647586 cites W2030578674 @default.
- W2460647586 cites W2035968282 @default.
- W2460647586 cites W2036219925 @default.
- W2460647586 cites W2039663629 @default.
- W2460647586 cites W2041119309 @default.
- W2460647586 cites W2045445369 @default.
- W2460647586 cites W2046027917 @default.
- W2460647586 cites W2046318104 @default.
- W2460647586 cites W2048109221 @default.
- W2460647586 cites W2052656852 @default.
- W2460647586 cites W2055809007 @default.
- W2460647586 cites W2056546853 @default.
- W2460647586 cites W2057090515 @default.
- W2460647586 cites W2059261163 @default.
- W2460647586 cites W2064016378 @default.
- W2460647586 cites W2064433079 @default.
- W2460647586 cites W2064752763 @default.
- W2460647586 cites W2070258464 @default.
- W2460647586 cites W2076777258 @default.
- W2460647586 cites W2079904359 @default.
- W2460647586 cites W2080435252 @default.
- W2460647586 cites W2090434004 @default.
- W2460647586 cites W2092099825 @default.
- W2460647586 cites W2092771760 @default.