FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460651270> ?p ?o ?g. }

• W2460651270 endingPage "905" @default.
• W2460651270 startingPage "901" @default.
• W2460651270 abstract "Mammary gland explants from pregnant (day 12-15) rats were cultured with insulin and prolactin, and their content and secretion of alpha-lactalbumin determined after exposure to a wide range of doses (0.01-300 nM) of the specific synthetic progestin (ORG2058), alone or with a maximally stimulatory dose of the highly specific glucocorticoid RU26988. ORG2058 alone suppressed alpha-lactalbumin synthesis below baseline, with a half-maximal effect at a concentration of less than 0.1 nM; RU26988-stimulated secretion was similarly abrogated by ORG2058, similarly with a half maximally effective dose of less than 0.1 nM. We interpret these data as suggesting that (i) given the specificity and doses of the steroids used the effect of progestins on alpha lactalbumin synthesis is directly via progesterone receptor occupancy, and not by competing with glucocorticoids for glucocorticoid receptors and (ii) given the shift to the left in the alpha-lactalbumin response (half maximal less than 0.1 nM ORG2058) compared with receptor binding (Kd (37 degrees C) greater than 1 nM), one possible model for such sensitivity is that of multiple, independent regulatory elements on the chromatin controlling alpha-lactalbumin gene expression, occupancy of any one of which by an activated progesterone receptor is sufficient to abrogate transcription." @default.
• W2460651270 created "2016-07-22" @default.
• W2460651270 creator A5012560593 @default.
• W2460651270 creator A5014385012 @default.
• W2460651270 creator A5019746134 @default.
• W2460651270 creator A5053353813 @default.
• W2460651270 date "1985-12-01" @default.
• W2460651270 modified "2023-09-27" @default.
• W2460651270 title "Progestins specifically suppress α-lactalbumin synthesis and secretion" @default.
• W2460651270 cites W1493175306 @default.
• W2460651270 cites W1499516889 @default.
• W2460651270 cites W1592350172 @default.
• W2460651270 cites W1598530978 @default.
• W2460651270 cites W1635738393 @default.
• W2460651270 cites W1716826009 @default.
• W2460651270 cites W1837711156 @default.
• W2460651270 cites W1873099258 @default.
• W2460651270 cites W1937480282 @default.
• W2460651270 cites W1965674339 @default.
• W2460651270 cites W1969190934 @default.
• W2460651270 cites W1974748049 @default.
• W2460651270 cites W1974942381 @default.
• W2460651270 cites W1981604367 @default.
• W2460651270 cites W1989210771 @default.
• W2460651270 cites W1999718090 @default.
• W2460651270 cites W2007737391 @default.
• W2460651270 cites W2012515679 @default.
• W2460651270 cites W2012796972 @default.
• W2460651270 cites W2013137776 @default.
• W2460651270 cites W2014943183 @default.
• W2460651270 cites W2020712454 @default.
• W2460651270 cites W2024485290 @default.
• W2460651270 cites W2025050741 @default.
• W2460651270 cites W2035524027 @default.
• W2460651270 cites W2037100837 @default.
• W2460651270 cites W2037152584 @default.
• W2460651270 cites W2042443871 @default.
• W2460651270 cites W2043204180 @default.
• W2460651270 cites W2046092060 @default.
• W2460651270 cites W2046776449 @default.
• W2460651270 cites W2047570451 @default.
• W2460651270 cites W2049004196 @default.
• W2460651270 cites W2050530322 @default.
• W2460651270 cites W2063878099 @default.
• W2460651270 cites W2079644568 @default.
• W2460651270 cites W2080066625 @default.
• W2460651270 cites W2080072126 @default.
• W2460651270 cites W2091296721 @default.
• W2460651270 cites W2110797151 @default.
• W2460651270 cites W2143309609 @default.
• W2460651270 cites W2197316737 @default.
• W2460651270 doi "https://doi.org/10.1016/0022-4731(85)90045-7" @default.
• W2460651270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3912614" @default.
• W2460651270 hasPublicationYear "1985" @default.
• W2460651270 type Work @default.
• W2460651270 sameAs 2460651270 @default.
• W2460651270 citedByCount "16" @default.
• W2460651270 countsByYear W24606512702012 @default.
• W2460651270 countsByYear W24606512702020 @default.
• W2460651270 countsByYear W24606512702021 @default.
• W2460651270 countsByYear W24606512702022 @default.
• W2460651270 crossrefType "journal-article" @default.
• W2460651270 hasAuthorship W2460651270A5012560593 @default.
• W2460651270 hasAuthorship W2460651270A5014385012 @default.
• W2460651270 hasAuthorship W2460651270A5019746134 @default.
• W2460651270 hasAuthorship W2460651270A5053353813 @default.
• W2460651270 hasConcept C126322002 @default.
• W2460651270 hasConcept C134018914 @default.
• W2460651270 hasConcept C170493617 @default.
• W2460651270 hasConcept C185592680 @default.
• W2460651270 hasConcept C2776607906 @default.
• W2460651270 hasConcept C2779064019 @default.
• W2460651270 hasConcept C2780352252 @default.
• W2460651270 hasConcept C2780841215 @default.
• W2460651270 hasConcept C49039625 @default.
• W2460651270 hasConcept C55493867 @default.
• W2460651270 hasConcept C59493245 @default.
• W2460651270 hasConcept C68863886 @default.
• W2460651270 hasConcept C71315377 @default.
• W2460651270 hasConcept C71924100 @default.
• W2460651270 hasConcept C86803240 @default.
• W2460651270 hasConceptScore W2460651270C126322002 @default.
• W2460651270 hasConceptScore W2460651270C134018914 @default.
• W2460651270 hasConceptScore W2460651270C170493617 @default.
• W2460651270 hasConceptScore W2460651270C185592680 @default.
• W2460651270 hasConceptScore W2460651270C2776607906 @default.
• W2460651270 hasConceptScore W2460651270C2779064019 @default.
• W2460651270 hasConceptScore W2460651270C2780352252 @default.
• W2460651270 hasConceptScore W2460651270C2780841215 @default.
• W2460651270 hasConceptScore W2460651270C49039625 @default.
• W2460651270 hasConceptScore W2460651270C55493867 @default.
• W2460651270 hasConceptScore W2460651270C59493245 @default.
• W2460651270 hasConceptScore W2460651270C68863886 @default.
• W2460651270 hasConceptScore W2460651270C71315377 @default.
• W2460651270 hasConceptScore W2460651270C71924100 @default.
• W2460651270 hasConceptScore W2460651270C86803240 @default.
• W2460651270 hasIssue "6" @default.
• W2460651270 hasLocation W24606512701 @default.

• next