Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460740900> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2460740900 endingPage "95" @default.
- W2460740900 startingPage "187" @default.
- W2460740900 abstract "We have employed a molecular biological approach to study the dynamic status of hippocampal opioid peptides in response to seizures elicited by different experimental models, such as electroconvulsive shocks (ECS) and amygdaloid kindling. Both ECS- and kindling-induced seizures triggered an initial large release of enkephalin and dynorphin, but produced opposite long-term effects on the biosynthesis of these two peptides, an increase of enkephalin, and a drastic decrease of dynorphin. Electrical stimulation of the perforant pathway produced differential changes of enkephalin and dynorphin, which were identical to those of ECS and kindling. This finding confirmed our hypothesis that the perforant pathway was responsible for the mediation of ECS- and kindling-induced changes in opioid peptide turnover. Strongest evidence indicating a role for opioid peptides in mediating the expression of seizure-related behaviors was found using the kainic acid model, where we saw that hippocampal enkephalin was essential to the expression of kainic acid-induced wet dog shakes (a preconvulsive shaking behavior). Furthermore, it was found that the granular-mossy fiber pathway of the ventral, but not the dorsal, hippocampus was essential for the expression of this shaking behavior. However, destruction of the granular-mossy fiber pathway potentiated the seizures and hippocampal cell loss induced by kainic acid. This unexpected, yet extremely interesting, finding not only distinguished the roles of the granular-mossy fiber pathway in mediating wet dog shakes vs. convulsive seizures, but also challenged the dogma that this granular-mossy fiber pathway is essential for the expression of limbic seizures." @default.
- W2460740900 created "2016-07-22" @default.
- W2460740900 creator A5086894115 @default.
- W2460740900 date "1992-01-01" @default.
- W2460740900 modified "2023-09-23" @default.
- W2460740900 title "Hippocampal opioid peptides and seizures." @default.
- W2460740900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1361330" @default.
- W2460740900 hasPublicationYear "1992" @default.
- W2460740900 type Work @default.
- W2460740900 sameAs 2460740900 @default.
- W2460740900 citedByCount "7" @default.
- W2460740900 countsByYear W24607409002015 @default.
- W2460740900 countsByYear W24607409002017 @default.
- W2460740900 countsByYear W24607409002020 @default.
- W2460740900 countsByYear W24607409002022 @default.
- W2460740900 crossrefType "journal-article" @default.
- W2460740900 hasAuthorship W2460740900A5086894115 @default.
- W2460740900 hasConcept C100691959 @default.
- W2460740900 hasConcept C126322002 @default.
- W2460740900 hasConcept C148762608 @default.
- W2460740900 hasConcept C151077648 @default.
- W2460740900 hasConcept C15744967 @default.
- W2460740900 hasConcept C169760540 @default.
- W2460740900 hasConcept C170493617 @default.
- W2460740900 hasConcept C185592680 @default.
- W2460740900 hasConcept C24998067 @default.
- W2460740900 hasConcept C2776108384 @default.
- W2460740900 hasConcept C2776168963 @default.
- W2460740900 hasConcept C2776464000 @default.
- W2460740900 hasConcept C2777318268 @default.
- W2460740900 hasConcept C2777803847 @default.
- W2460740900 hasConcept C2778302826 @default.
- W2460740900 hasConcept C2781063702 @default.
- W2460740900 hasConcept C2781161787 @default.
- W2460740900 hasConcept C2911154596 @default.
- W2460740900 hasConcept C55493867 @default.
- W2460740900 hasConcept C61174792 @default.
- W2460740900 hasConcept C71924100 @default.
- W2460740900 hasConcept C88016717 @default.
- W2460740900 hasConceptScore W2460740900C100691959 @default.
- W2460740900 hasConceptScore W2460740900C126322002 @default.
- W2460740900 hasConceptScore W2460740900C148762608 @default.
- W2460740900 hasConceptScore W2460740900C151077648 @default.
- W2460740900 hasConceptScore W2460740900C15744967 @default.
- W2460740900 hasConceptScore W2460740900C169760540 @default.
- W2460740900 hasConceptScore W2460740900C170493617 @default.
- W2460740900 hasConceptScore W2460740900C185592680 @default.
- W2460740900 hasConceptScore W2460740900C24998067 @default.
- W2460740900 hasConceptScore W2460740900C2776108384 @default.
- W2460740900 hasConceptScore W2460740900C2776168963 @default.
- W2460740900 hasConceptScore W2460740900C2776464000 @default.
- W2460740900 hasConceptScore W2460740900C2777318268 @default.
- W2460740900 hasConceptScore W2460740900C2777803847 @default.
- W2460740900 hasConceptScore W2460740900C2778302826 @default.
- W2460740900 hasConceptScore W2460740900C2781063702 @default.
- W2460740900 hasConceptScore W2460740900C2781161787 @default.
- W2460740900 hasConceptScore W2460740900C2911154596 @default.
- W2460740900 hasConceptScore W2460740900C55493867 @default.
- W2460740900 hasConceptScore W2460740900C61174792 @default.
- W2460740900 hasConceptScore W2460740900C71924100 @default.
- W2460740900 hasConceptScore W2460740900C88016717 @default.
- W2460740900 hasLocation W24607409001 @default.
- W2460740900 hasOpenAccess W2460740900 @default.
- W2460740900 hasPrimaryLocation W24607409001 @default.
- W2460740900 hasRelatedWork W1972785969 @default.
- W2460740900 hasRelatedWork W2003186917 @default.
- W2460740900 hasRelatedWork W2016815767 @default.
- W2460740900 hasRelatedWork W2077369265 @default.
- W2460740900 hasRelatedWork W2077704288 @default.
- W2460740900 hasRelatedWork W2088017716 @default.
- W2460740900 hasRelatedWork W2092345381 @default.
- W2460740900 hasRelatedWork W2093970110 @default.
- W2460740900 hasRelatedWork W2460740900 @default.
- W2460740900 hasRelatedWork W3029937632 @default.
- W2460740900 hasVolume "7" @default.
- W2460740900 isParatext "false" @default.
- W2460740900 isRetracted "false" @default.
- W2460740900 magId "2460740900" @default.
- W2460740900 workType "article" @default.