FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2460753863> ?p ?o ?g. }

• W2460753863 endingPage "819" @default.
• W2460753863 startingPage "807" @default.
• W2460753863 abstract "Epithelial-mesenchymal transition (EMT) is a critical event in metastasis of colorectal cancer (CRC). Rho/ROCKs signaling has a pivotal role in orchestrating actin cytoskeleton, leading to EMT and cancer invasion. However, the underlying mechanisms for ROCKs activation are not fully understood. Here, we identified FOXM1D, a novel isoform of Forkhead box M1 (FOXM1) that has a pivotal role in ROCKs activation by directly interacting with coiled-coil region of ROCK2. FOXM1D overexpression significantly polymerizes actin assembly and impairs E-cadherin expression, resulting in EMT and metastasis in xenograft mouse model and knockdown of FOXM1D has the opposite effect. Moreover, a high FOXM1D level correlates closely with clinical CRC metastasis. FOXM1D-induced ROCKs activation could be abrogated by the ROCKs inhibitors Y-27632 and fasudil. These observations indicate that the FOXM1D-ROCK2 interaction is crucial for Rho/ROCKs signaling and provide novel insight into actin cytoskeleton regulation and therapeutic potential for CRC metastasis." @default.
• W2460753863 created "2016-07-22" @default.
• W2460753863 creator A5012463050 @default.
• W2460753863 creator A5023547621 @default.
• W2460753863 creator A5024388681 @default.
• W2460753863 creator A5028744204 @default.
• W2460753863 creator A5029571874 @default.
• W2460753863 creator A5034555717 @default.
• W2460753863 creator A5035369227 @default.
• W2460753863 creator A5040074001 @default.
• W2460753863 creator A5048043733 @default.
• W2460753863 creator A5055644158 @default.
• W2460753863 creator A5056482530 @default.
• W2460753863 creator A5062183772 @default.
• W2460753863 creator A5064154645 @default.
• W2460753863 creator A5068062810 @default.
• W2460753863 creator A5068797894 @default.
• W2460753863 creator A5070685116 @default.
• W2460753863 creator A5073148720 @default.
• W2460753863 creator A5084082326 @default.
• W2460753863 creator A5090242706 @default.
• W2460753863 date "2016-07-11" @default.
• W2460753863 modified "2023-10-16" @default.
• W2460753863 title "A novel FOXM1 isoform, FOXM1D, promotes epithelial–mesenchymal transition and metastasis through ROCKs activation in colorectal cancer" @default.
• W2460753863 cites W1840802607 @default.
• W2460753863 cites W1916084024 @default.
• W2460753863 cites W193610742 @default.
• W2460753863 cites W1964847767 @default.
• W2460753863 cites W1965183553 @default.
• W2460753863 cites W1969037652 @default.
• W2460753863 cites W1973580165 @default.
• W2460753863 cites W1978677176 @default.
• W2460753863 cites W1984018823 @default.
• W2460753863 cites W1984708567 @default.
• W2460753863 cites W1988729236 @default.
• W2460753863 cites W1999278779 @default.
• W2460753863 cites W2002373478 @default.
• W2460753863 cites W2016162029 @default.
• W2460753863 cites W2019731805 @default.
• W2460753863 cites W2026136425 @default.
• W2460753863 cites W2026228115 @default.
• W2460753863 cites W2077330772 @default.
• W2460753863 cites W2077462602 @default.
• W2460753863 cites W2077560715 @default.
• W2460753863 cites W2077603983 @default.
• W2460753863 cites W2080232352 @default.
• W2460753863 cites W2089680712 @default.
• W2460753863 cites W2099170646 @default.
• W2460753863 cites W2105274913 @default.
• W2460753863 cites W2111807830 @default.
• W2460753863 cites W2115662954 @default.
• W2460753863 cites W2119702047 @default.
• W2460753863 cites W2135630561 @default.
• W2460753863 cites W2136741329 @default.
• W2460753863 cites W2138897067 @default.
• W2460753863 cites W2142978362 @default.
• W2460753863 cites W2146867769 @default.
• W2460753863 cites W2149972103 @default.
• W2460753863 cites W2154345686 @default.
• W2460753863 cites W2155369806 @default.
• W2460753863 cites W2156122059 @default.
• W2460753863 cites W2166802464 @default.
• W2460753863 cites W2169300384 @default.
• W2460753863 cites W2169961966 @default.
• W2460753863 cites W2219978888 @default.
• W2460753863 cites W2375169070 @default.
• W2460753863 cites W32449127 @default.
• W2460753863 doi "https://doi.org/10.1038/onc.2016.249" @default.
• W2460753863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5311249" @default.
• W2460753863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27399334" @default.
• W2460753863 hasPublicationYear "2016" @default.
• W2460753863 type Work @default.
• W2460753863 sameAs 2460753863 @default.
• W2460753863 citedByCount "44" @default.
• W2460753863 countsByYear W24607538632016 @default.
• W2460753863 countsByYear W24607538632017 @default.
• W2460753863 countsByYear W24607538632018 @default.
• W2460753863 countsByYear W24607538632019 @default.
• W2460753863 countsByYear W24607538632020 @default.
• W2460753863 countsByYear W24607538632021 @default.
• W2460753863 countsByYear W24607538632022 @default.
• W2460753863 countsByYear W24607538632023 @default.
• W2460753863 crossrefType "journal-article" @default.
• W2460753863 hasAuthorship W2460753863A5012463050 @default.
• W2460753863 hasAuthorship W2460753863A5023547621 @default.
• W2460753863 hasAuthorship W2460753863A5024388681 @default.
• W2460753863 hasAuthorship W2460753863A5028744204 @default.
• W2460753863 hasAuthorship W2460753863A5029571874 @default.
• W2460753863 hasAuthorship W2460753863A5034555717 @default.
• W2460753863 hasAuthorship W2460753863A5035369227 @default.
• W2460753863 hasAuthorship W2460753863A5040074001 @default.
• W2460753863 hasAuthorship W2460753863A5048043733 @default.
• W2460753863 hasAuthorship W2460753863A5055644158 @default.
• W2460753863 hasAuthorship W2460753863A5056482530 @default.
• W2460753863 hasAuthorship W2460753863A5062183772 @default.
• W2460753863 hasAuthorship W2460753863A5064154645 @default.
• W2460753863 hasAuthorship W2460753863A5068062810 @default.
• W2460753863 hasAuthorship W2460753863A5068797894 @default.

• next