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• W2460844087 startingPage "475" @default.
• W2460844087 abstract "Multicomponent reactions (MCRs) have become a powerful tool for drug discovery and development owing to their advantages of fast and efficient construction of a large library of products with complexity and diversity. However, conventional MCRs usually proceed in environmentally unfriendly organic solvents rather than in water, a green solvent used by nature for biological chemistry. Herein, a simple and efficient on-water urea-catalyzed chemoselective five-component reaction (5CR) has been developed for the synthesis of a series of novel octahydroquinazoline-5-ones (6), the derivatives of quinazolinones possessing diverse biological activities. The molecular structure of 6{1,1,12} has been confirmed by single-crystal X-ray diffraction. The 5CR can proceed at room temperature under normal atmospheric pressure in good yields and afford a large library of octahydroquinazoline-5-ones with various aromatic and aliphatic substituents at N-1, C-2, and N-3. In addition, a green method has been developed for the synthesis of enaminones, important intermediates in the 5CR and in synthetic chemistry." @default.
• W2460844087 created "2016-07-22" @default.
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• W2460844087 date "2016-07-22" @default.
• W2460844087 modified "2023-09-24" @default.
• W2460844087 title "Efficient Synthesis of a Series of Novel Octahydroquinazoline-5-ones via a Simple on-Water Urea-Catalyzed Chemoselective Five-Component Reaction" @default.
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• W2460844087 doi "https://doi.org/10.1021/acscombsci.6b00038" @default.
• W2460844087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27355661" @default.
• W2460844087 hasPublicationYear "2016" @default.
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