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- W2461035333 abstract "During the 1960s, rabbit platelets were found to release histamine by a mechanism that was leukocyte- and antigen-dependent 1-3. The leukocytes were thought to provide a factor actively released by a calcium- and temperature-dependent process4,5; later, Benveniste et a/. 6.7, described the methodology to obtain this substance which they termed platelet-activating factor (PAF)*. They initiated its characterization and showed that it was released from rabbit basophils by an IgEdependent process, while subsequent structural elucidation demonstrated that PAF is 1-alkyl-2(R)-acetyl-glycero3-phosphocholine 8.9, a phospholipid sensitive to phospholipase A2 (Refs 8,10,11). The two principal molecular species of PAF produced by human neutrophils or rabbit basophils have a hexadecyl or octadecyl alkyl moiety, but more sophisticated separation techniques have demonstrated that PAF is composed of at least 16 molecular species containing saturated or unsaturated alkyl or acyl chains, or even a polar head group other than choline12,13" @default.
- W2461035333 created "2016-07-22" @default.
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- W2461035333 date "1987-01-01" @default.
- W2461035333 modified "2023-09-27" @default.
- W2461035333 title "Platelet-adivating factor and cellular" @default.
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- W2461035333 hasPublicationYear "1987" @default.
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