FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461036983> ?p ?o ?g. }

• W2461036983 endingPage "204173141664978" @default.
• W2461036983 startingPage "204173141664978" @default.
• W2461036983 abstract "An attractive strategy for the regeneration of tissues has been the use of extracellular matrix analogous biomaterials. Peptide-based fibrillar hydrogels have been shown to mimic the structure of extracellular matrix offering cells a niche to undertake their physiological functions. In this study, the capability of an ionic-complementary peptide FEFEFKFK (F, E, and K are phenylalanine, glutamic acid, and lysine, respectively) hydrogel to host human mesenchymal stem cells in three dimensions and induce their osteogenic differentiation is demonstrated. Assays showed sustained cell viability and proliferation throughout the hydrogel over 12 days of culture and these human mesenchymal stem cells differentiated into osteoblasts simply upon addition of osteogenic stimulation. Differentiated osteoblasts synthesized key bone proteins, including collagen-1 (Col-1), osteocalcin, and alkaline phosphatase. Moreover, mineralization occurred within the hydrogel. The peptide hydrogel is a naturally biodegradable material as shown by oscillatory rheology and reversed-phase high-performance liquid chromatography, where both viscoelastic properties and the degradation of the hydrogel were monitored over time, respectively. These findings demonstrate that a biodegradable octapeptide hydrogel can host and induce the differentiation of stem cells and has the potential for the regeneration of hard tissues such as alveolar bone." @default.
• W2461036983 created "2016-07-22" @default.
• W2461036983 creator A5006610972 @default.
• W2461036983 creator A5014535145 @default.
• W2461036983 creator A5025282034 @default.
• W2461036983 creator A5028515943 @default.
• W2461036983 creator A5048778407 @default.
• W2461036983 date "2016-01-01" @default.
• W2461036983 modified "2023-10-12" @default.
• W2461036983 title "Osteogenic differentiation of human mesenchymal stem cells promotes mineralization within a biodegradable peptide hydrogel" @default.
• W2461036983 cites W1581251915 @default.
• W2461036983 cites W1964895653 @default.
• W2461036983 cites W1969118281 @default.
• W2461036983 cites W1969750812 @default.
• W2461036983 cites W1971316735 @default.
• W2461036983 cites W1978969388 @default.
• W2461036983 cites W1981137122 @default.
• W2461036983 cites W1982457774 @default.
• W2461036983 cites W1990069138 @default.
• W2461036983 cites W1992340488 @default.
• W2461036983 cites W1992594866 @default.
• W2461036983 cites W1993679579 @default.
• W2461036983 cites W2003425602 @default.
• W2461036983 cites W2004618997 @default.
• W2461036983 cites W2005307198 @default.
• W2461036983 cites W2008067928 @default.
• W2461036983 cites W2008850772 @default.
• W2461036983 cites W2017347042 @default.
• W2461036983 cites W2020075958 @default.
• W2461036983 cites W2021550972 @default.
• W2461036983 cites W2029945135 @default.
• W2461036983 cites W2031776886 @default.
• W2461036983 cites W2032502175 @default.
• W2461036983 cites W2036278706 @default.
• W2461036983 cites W2039030534 @default.
• W2461036983 cites W2039229042 @default.
• W2461036983 cites W2043011130 @default.
• W2461036983 cites W2054992092 @default.
• W2461036983 cites W2058500387 @default.
• W2461036983 cites W2058839233 @default.
• W2461036983 cites W2064498912 @default.
• W2461036983 cites W2077050947 @default.
• W2461036983 cites W2079439718 @default.
• W2461036983 cites W2085390592 @default.
• W2461036983 cites W2087578260 @default.
• W2461036983 cites W2089401957 @default.
• W2461036983 cites W2090178061 @default.
• W2461036983 cites W2094281264 @default.
• W2461036983 cites W2097220572 @default.
• W2461036983 cites W2098737512 @default.
• W2461036983 cites W2104065432 @default.
• W2461036983 cites W2108465565 @default.
• W2461036983 cites W2109916620 @default.
• W2461036983 cites W2111471786 @default.
• W2461036983 cites W2123678968 @default.
• W2461036983 cites W2126111746 @default.
• W2461036983 cites W2130387237 @default.
• W2461036983 cites W2132131875 @default.
• W2461036983 cites W2133514604 @default.
• W2461036983 cites W2134208433 @default.
• W2461036983 cites W2134292086 @default.
• W2461036983 cites W2136116635 @default.
• W2461036983 cites W2138889138 @default.
• W2461036983 cites W2142816998 @default.
• W2461036983 cites W2155677305 @default.
• W2461036983 cites W2162406068 @default.
• W2461036983 cites W2166266977 @default.
• W2461036983 cites W2172039469 @default.
• W2461036983 cites W2279832128 @default.
• W2461036983 cites W2335489080 @default.
• W2461036983 cites W4211075268 @default.
• W2461036983 doi "https://doi.org/10.1177/2041731416649789" @default.
• W2461036983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4959308" @default.
• W2461036983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27493714" @default.
• W2461036983 hasPublicationYear "2016" @default.
• W2461036983 type Work @default.
• W2461036983 sameAs 2461036983 @default.
• W2461036983 citedByCount "62" @default.
• W2461036983 countsByYear W24610369832016 @default.
• W2461036983 countsByYear W24610369832017 @default.
• W2461036983 countsByYear W24610369832018 @default.
• W2461036983 countsByYear W24610369832019 @default.
• W2461036983 countsByYear W24610369832020 @default.
• W2461036983 countsByYear W24610369832021 @default.
• W2461036983 countsByYear W24610369832022 @default.
• W2461036983 countsByYear W24610369832023 @default.
• W2461036983 crossrefType "journal-article" @default.
• W2461036983 hasAuthorship W2461036983A5006610972 @default.
• W2461036983 hasAuthorship W2461036983A5014535145 @default.
• W2461036983 hasAuthorship W2461036983A5025282034 @default.
• W2461036983 hasAuthorship W2461036983A5028515943 @default.
• W2461036983 hasAuthorship W2461036983A5048778407 @default.
• W2461036983 hasBestOaLocation W24610369831 @default.
• W2461036983 hasConcept C104317684 @default.
• W2461036983 hasConcept C108586683 @default.
• W2461036983 hasConcept C111696902 @default.
• W2461036983 hasConcept C12554922 @default.
• W2461036983 hasConcept C131075544 @default.

• next