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- W2461078723 endingPage "458" @default.
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- W2461078723 abstract "Purpose of review Primary cilia have become important organelles implicated in embryonic development, organogenesis, health, and diseases. Although many studies in cell biology have focused on changes in ciliary length or ciliogenesis, the most common readout for evaluating ciliary function is intracellular calcium. Recent findings Recent tools have allowed us to examine intracellular calcium in more precise locations, that is, the cilioplasm and cytoplasm. Advances in calcium imaging have also allowed us to identify which cilia respond to particular stimuli. Furthermore, direct electrophysiological measurement of ionic currents within a cilium has provided a wealth of information for understanding the sensory roles of primary cilia. Summary Calcium imaging and direct measurement of calcium currents demonstrate that primary cilia are sensory organelles that house several types of functional calcium channels. Although intracellular calcium now allows a functional readout for primary cilia, discussions on the relative contributions of the several channel types have just begun. Perhaps, all of these calcium channels are required and necessary to differentiate stimuli in different microenvironments." @default.
- W2461078723 created "2016-07-22" @default.
- W2461078723 creator A5000688565 @default.
- W2461078723 creator A5029926919 @default.
- W2461078723 creator A5088032785 @default.
- W2461078723 date "2016-09-01" @default.
- W2461078723 modified "2023-10-01" @default.
- W2461078723 title "Calcium channels in primary cilia" @default.
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- W2461078723 doi "https://doi.org/10.1097/mnh.0000000000000251" @default.
- W2461078723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4974130" @default.
- W2461078723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27341444" @default.
- W2461078723 hasPublicationYear "2016" @default.
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