Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461126290> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2461126290 endingPage "84" @default.
- W2461126290 startingPage "179" @default.
- W2461126290 abstract "The effects of phencyclidine (PCP) and phencyclidine methiodide (PCP-MeI) on contractions of longitudinal muscle of guinea pig ileum and specific binding of [3H](DL)3-quinuclidinyl benzilate ([3H]QNB) to muscarinic receptors in these muscles and rat brain were studied. PCP inhibited competitively muscarinic agonist-induced contractions of the longitudinal muscle of guinea pig ileum at concentrations below 10 µM (Ki = 0.45 µM). However, at 50 µM noncompetitive blockade of contraction was seen. In contrast, PCP-MeI inhibited ileum contractions competitively at concentrations of up to 100 µM (Ki = 0.2 µM). Both drugs inhibited binding of [3H]QNB to muscarinic acetylcholine (ACh) receptors of rat cerebral cortex and brain stem and to ileal longitudinal muscle (apparent Ki’s of from 0.8 to 3.7 µM). There was no evidence of noncompetitive receptor binding inhibition at PCP concentrations which produced noncompetitive inhibition of smooth muscle contraction. There were no indications of multiple receptor populations, cooperative interactions, or receptor isomerization with either drug. PCP-MeI was slightly more potent in its competitive muscarinic actions than PCP. Although the dissociation constant (Kd) of PCP from muscarinic receptors in brain cortex was significantly lower than in brain stem, the Kd values for PCP-MeI were the same. Treatment with N-ethylmaleimide did not affect the inhibition of [3H]QNB binding to muscarinic receptors by PCP. Based on several characteristics of the inhibition by PCP and PCP-MeI of [3H]QNB binding to rat brain muscarinic receptors and their inhibition of the contractions of longitudinal muscle of guinea pig ileum, PCP and PCP-MeI are considered antagonists of muscarmnic receptors in rat brain." @default.
- W2461126290 created "2016-07-22" @default.
- W2461126290 creator A5024270716 @default.
- W2461126290 creator A5059817376 @default.
- W2461126290 creator A5064308390 @default.
- W2461126290 creator A5076997420 @default.
- W2461126290 creator A5080210143 @default.
- W2461126290 creator A5082985493 @default.
- W2461126290 date "1980-09-01" @default.
- W2461126290 modified "2023-09-23" @default.
- W2461126290 title "Sites of action of phencyclidine. III. Interactions with muscarinic receptors." @default.
- W2461126290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7421791" @default.
- W2461126290 hasPublicationYear "1980" @default.
- W2461126290 type Work @default.
- W2461126290 sameAs 2461126290 @default.
- W2461126290 citedByCount "25" @default.
- W2461126290 countsByYear W24611262902015 @default.
- W2461126290 crossrefType "journal-article" @default.
- W2461126290 hasAuthorship W2461126290A5024270716 @default.
- W2461126290 hasAuthorship W2461126290A5059817376 @default.
- W2461126290 hasAuthorship W2461126290A5064308390 @default.
- W2461126290 hasAuthorship W2461126290A5076997420 @default.
- W2461126290 hasAuthorship W2461126290A5080210143 @default.
- W2461126290 hasAuthorship W2461126290A5082985493 @default.
- W2461126290 hasConcept C126322002 @default.
- W2461126290 hasConcept C134018914 @default.
- W2461126290 hasConcept C170493617 @default.
- W2461126290 hasConcept C185592680 @default.
- W2461126290 hasConcept C207723603 @default.
- W2461126290 hasConcept C2775910092 @default.
- W2461126290 hasConcept C2778851735 @default.
- W2461126290 hasConcept C2778938600 @default.
- W2461126290 hasConcept C33789571 @default.
- W2461126290 hasConcept C47488739 @default.
- W2461126290 hasConcept C55493867 @default.
- W2461126290 hasConcept C64123433 @default.
- W2461126290 hasConcept C67018056 @default.
- W2461126290 hasConcept C71924100 @default.
- W2461126290 hasConcept C86803240 @default.
- W2461126290 hasConcept C98274493 @default.
- W2461126290 hasConceptScore W2461126290C126322002 @default.
- W2461126290 hasConceptScore W2461126290C134018914 @default.
- W2461126290 hasConceptScore W2461126290C170493617 @default.
- W2461126290 hasConceptScore W2461126290C185592680 @default.
- W2461126290 hasConceptScore W2461126290C207723603 @default.
- W2461126290 hasConceptScore W2461126290C2775910092 @default.
- W2461126290 hasConceptScore W2461126290C2778851735 @default.
- W2461126290 hasConceptScore W2461126290C2778938600 @default.
- W2461126290 hasConceptScore W2461126290C33789571 @default.
- W2461126290 hasConceptScore W2461126290C47488739 @default.
- W2461126290 hasConceptScore W2461126290C55493867 @default.
- W2461126290 hasConceptScore W2461126290C64123433 @default.
- W2461126290 hasConceptScore W2461126290C67018056 @default.
- W2461126290 hasConceptScore W2461126290C71924100 @default.
- W2461126290 hasConceptScore W2461126290C86803240 @default.
- W2461126290 hasConceptScore W2461126290C98274493 @default.
- W2461126290 hasIssue "2" @default.
- W2461126290 hasLocation W24611262901 @default.
- W2461126290 hasOpenAccess W2461126290 @default.
- W2461126290 hasPrimaryLocation W24611262901 @default.
- W2461126290 hasRelatedWork W1980648631 @default.
- W2461126290 hasRelatedWork W1989572166 @default.
- W2461126290 hasRelatedWork W2005072877 @default.
- W2461126290 hasRelatedWork W2025714737 @default.
- W2461126290 hasRelatedWork W2028568597 @default.
- W2461126290 hasRelatedWork W2124584269 @default.
- W2461126290 hasRelatedWork W2607211746 @default.
- W2461126290 hasRelatedWork W2899084033 @default.
- W2461126290 hasRelatedWork W4280600229 @default.
- W2461126290 hasRelatedWork W2022574318 @default.
- W2461126290 hasVolume "18" @default.
- W2461126290 isParatext "false" @default.
- W2461126290 isRetracted "false" @default.
- W2461126290 magId "2461126290" @default.
- W2461126290 workType "article" @default.