Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461329191> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2461329191 abstract "In the present study we synthesized different N-terminal fragments and analogues of the C-terminal octapeptide of cholecystokinin [CCK-(26-33)] and examined their actions on dispersed acini prepared from guinea pig pancreas. None of the N-terminal fragments or analogues altered basal amylase release. Analogues of CCK-(26-32), CCK-(26-31), and CCK-(26-30) inhibited CCK-(26-33)-stimulated amylase, and there was a close correlation between the ability of an analogue to inhibit stimulated amylase and the analogue's ability to inhibit binding of 125I-cholecystokinin. N-acetyl-CCK-(26-29)-amide at concentrations as high as 100 microM did not inhibit CCK-(26-33)-stimulated amylase release or binding of 125I-CCK. For those analogues that antagonized CCK-(26-33)-stimulated amylase release the antagonism was of the competitive type and was specific for those secretagogues that interact with the cholecystokinin receptor. Removing the C-terminal amide from N-acetyl-CCK-(26-31)-amide caused a 10-fold decrease in the inhibitory potency, whereas removing the C-terminal amide from N-acetyl-CCK-(26-30)-amide did not alter the inhibitory potency of the peptide. Removing the sulfate ester from the tyrosine residue in position 27 of N-acetyl-CCK-(26-31) did not alter the inhibitory potency of the peptide, whereas removing the sulfate ester from the tyrosine residue in position 27 of N-acetyl-(26-30) caused a three- to fivefold decrease in the inhibitory potency of the peptide.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2461329191 created "2016-07-22" @default.
- W2461329191 creator A5004146418 @default.
- W2461329191 creator A5081368941 @default.
- W2461329191 creator A5082407261 @default.
- W2461329191 creator A5087354083 @default.
- W2461329191 date "1985-01-01" @default.
- W2461329191 modified "2023-09-27" @default.
- W2461329191 title "N-terminal fragments of CCK-(26-33) as cholecystokinin receptor antagonists in guinea pig pancreatic acini" @default.
- W2461329191 doi "https://doi.org/10.1152/ajpgi.1985.248.1.g98" @default.
- W2461329191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2578257" @default.
- W2461329191 hasPublicationYear "1985" @default.
- W2461329191 type Work @default.
- W2461329191 sameAs 2461329191 @default.
- W2461329191 citedByCount "1" @default.
- W2461329191 crossrefType "journal-article" @default.
- W2461329191 hasAuthorship W2461329191A5004146418 @default.
- W2461329191 hasAuthorship W2461329191A5081368941 @default.
- W2461329191 hasAuthorship W2461329191A5082407261 @default.
- W2461329191 hasAuthorship W2461329191A5087354083 @default.
- W2461329191 hasConcept C134018914 @default.
- W2461329191 hasConcept C170493617 @default.
- W2461329191 hasConcept C170835558 @default.
- W2461329191 hasConcept C181199279 @default.
- W2461329191 hasConcept C185592680 @default.
- W2461329191 hasConcept C202751555 @default.
- W2461329191 hasConcept C2776165026 @default.
- W2461329191 hasConcept C2777593968 @default.
- W2461329191 hasConcept C2778815084 @default.
- W2461329191 hasConcept C2779281246 @default.
- W2461329191 hasConcept C32110497 @default.
- W2461329191 hasConcept C55493867 @default.
- W2461329191 hasConcept C57992300 @default.
- W2461329191 hasConcept C71240020 @default.
- W2461329191 hasConcept C86803240 @default.
- W2461329191 hasConceptScore W2461329191C134018914 @default.
- W2461329191 hasConceptScore W2461329191C170493617 @default.
- W2461329191 hasConceptScore W2461329191C170835558 @default.
- W2461329191 hasConceptScore W2461329191C181199279 @default.
- W2461329191 hasConceptScore W2461329191C185592680 @default.
- W2461329191 hasConceptScore W2461329191C202751555 @default.
- W2461329191 hasConceptScore W2461329191C2776165026 @default.
- W2461329191 hasConceptScore W2461329191C2777593968 @default.
- W2461329191 hasConceptScore W2461329191C2778815084 @default.
- W2461329191 hasConceptScore W2461329191C2779281246 @default.
- W2461329191 hasConceptScore W2461329191C32110497 @default.
- W2461329191 hasConceptScore W2461329191C55493867 @default.
- W2461329191 hasConceptScore W2461329191C57992300 @default.
- W2461329191 hasConceptScore W2461329191C71240020 @default.
- W2461329191 hasConceptScore W2461329191C86803240 @default.
- W2461329191 hasLocation W24613291911 @default.
- W2461329191 hasLocation W24613291912 @default.
- W2461329191 hasOpenAccess W2461329191 @default.
- W2461329191 hasPrimaryLocation W24613291911 @default.
- W2461329191 hasRelatedWork W1533636069 @default.
- W2461329191 hasRelatedWork W1982319478 @default.
- W2461329191 hasRelatedWork W1983240980 @default.
- W2461329191 hasRelatedWork W2000032612 @default.
- W2461329191 hasRelatedWork W2038810068 @default.
- W2461329191 hasRelatedWork W2110110717 @default.
- W2461329191 hasRelatedWork W2158435862 @default.
- W2461329191 hasRelatedWork W2413052940 @default.
- W2461329191 hasRelatedWork W2413103493 @default.
- W2461329191 hasRelatedWork W4810758 @default.
- W2461329191 isParatext "false" @default.
- W2461329191 isRetracted "false" @default.
- W2461329191 magId "2461329191" @default.
- W2461329191 workType "article" @default.