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- W2461338629 abstract "Objective To investigate whether taerine and donepezil can prevent apeptosis induced by Lipopolysaecharides. Methods Phaze-contrast microscopes was used to observe the morphological changes of Vero cells.Cell counting kit-8 was used to measure cell survival vitro. DNA fragment was analyzed by agarose gel electrophoresis to determine the apeptotic biochemical changes. Results Veto cells treated with 400 μg/ml and 500 μg/ml Lipopolysaccharides exhibited cell apoptosis. 10 μmol/L tacrine provided protective effect to 500 μg/ml Lipepolysaecharides induced cell apoptosis measured by Phase-contrast microscopes,cell counting kit-8 and DNA fragment analyze. However,donepezil did not show any protective effect of the apeptosis induced by 500 μg/ml Lipopolysaecharides. Conclusion Lipopolysaecharides can induce apeptosis in Veto cells to built an apoptotic model in vitro. Tacrine rather than donepezil can inhibit Lipopolysaecharides induced apoptosis in Veto cells.Key words: Hepatitis B; Apeptosis; Lipepolysaccharides; Tacrine; Donepezil" @default.
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- W2461338629 date "2008-12-01" @default.
- W2461338629 modified "2023-09-27" @default.
- W2461338629 title "Protection effects of acetylcholinesterase inhibitors on apoptosis" @default.
- W2461338629 doi "https://doi.org/10.3760/cma.j.issn.1003-9279.2008.06.020" @default.
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