Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461377241> ?p ?o ?g. }
- W2461377241 endingPage "e1006128" @default.
- W2461377241 startingPage "e1006128" @default.
- W2461377241 abstract "TAF4b is a gonadal-enriched subunit of the general transcription factor TFIID that is implicated in promoting healthy ovarian aging and female fertility in mice and humans. To further explore the potential mechanism of TAF4b in promoting ovarian follicle development, we analyzed global gene expression at multiple time points in the human fetal ovary. This computational analysis revealed coordinate expression of human TAF4B and critical regulators and effectors of meiosis I including SYCP3, YBX2, STAG3, and DAZL. To address the functional relevance of this analysis, we turned to the embryonic Taf4b-deficient mouse ovary where, for the first time, we demonstrate, severe deficits in prophase I progression as well as asynapsis in Taf4b-deficient oocytes. Accordingly, TAF4b occupies the proximal promoters of many essential meiosis and oogenesis regulators, including Stra8, Dazl, Figla, and Nobox, and is required for their proper expression. These data reveal a novel TAF4b function in regulating a meiotic gene expression program in early mouse oogenesis, and support the existence of a highly conserved TAF4b-dependent gene regulatory network promoting early oocyte development in both mice and women." @default.
- W2461377241 created "2016-07-22" @default.
- W2461377241 creator A5012263073 @default.
- W2461377241 creator A5016888668 @default.
- W2461377241 creator A5026630563 @default.
- W2461377241 creator A5027601058 @default.
- W2461377241 creator A5041628351 @default.
- W2461377241 creator A5043385984 @default.
- W2461377241 creator A5048946015 @default.
- W2461377241 creator A5071251376 @default.
- W2461377241 creator A5089449964 @default.
- W2461377241 date "2016-06-24" @default.
- W2461377241 modified "2023-10-14" @default.
- W2461377241 title "TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis" @default.
- W2461377241 cites W1480699894 @default.
- W2461377241 cites W1530897177 @default.
- W2461377241 cites W1813005480 @default.
- W2461377241 cites W1961869750 @default.
- W2461377241 cites W1970159856 @default.
- W2461377241 cites W1978834783 @default.
- W2461377241 cites W1979291624 @default.
- W2461377241 cites W1981323595 @default.
- W2461377241 cites W1983902581 @default.
- W2461377241 cites W1989176196 @default.
- W2461377241 cites W1990257071 @default.
- W2461377241 cites W1990699200 @default.
- W2461377241 cites W1994831927 @default.
- W2461377241 cites W1997311184 @default.
- W2461377241 cites W2010192783 @default.
- W2461377241 cites W2022127993 @default.
- W2461377241 cites W2024041649 @default.
- W2461377241 cites W2035082076 @default.
- W2461377241 cites W2042767445 @default.
- W2461377241 cites W2048501605 @default.
- W2461377241 cites W2048943430 @default.
- W2461377241 cites W2049804461 @default.
- W2461377241 cites W2051268087 @default.
- W2461377241 cites W2054305990 @default.
- W2461377241 cites W2057844875 @default.
- W2461377241 cites W2060842641 @default.
- W2461377241 cites W2067700245 @default.
- W2461377241 cites W2075029530 @default.
- W2461377241 cites W2089111937 @default.
- W2461377241 cites W2099189683 @default.
- W2461377241 cites W2099448734 @default.
- W2461377241 cites W2101650794 @default.
- W2461377241 cites W2116186946 @default.
- W2461377241 cites W2122954165 @default.
- W2461377241 cites W2134710117 @default.
- W2461377241 cites W2134850124 @default.
- W2461377241 cites W2136063036 @default.
- W2461377241 cites W2137360098 @default.
- W2461377241 cites W2139909146 @default.
- W2461377241 cites W2140897335 @default.
- W2461377241 cites W2151727566 @default.
- W2461377241 cites W2153654530 @default.
- W2461377241 cites W2157103338 @default.
- W2461377241 cites W2162488373 @default.
- W2461377241 cites W2162557211 @default.
- W2461377241 cites W2172041539 @default.
- W2461377241 cites W2215595807 @default.
- W2461377241 cites W2337778705 @default.
- W2461377241 cites W4233193355 @default.
- W2461377241 doi "https://doi.org/10.1371/journal.pgen.1006128" @default.
- W2461377241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4920394" @default.
- W2461377241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27341508" @default.
- W2461377241 hasPublicationYear "2016" @default.
- W2461377241 type Work @default.
- W2461377241 sameAs 2461377241 @default.
- W2461377241 citedByCount "24" @default.
- W2461377241 countsByYear W24613772412017 @default.
- W2461377241 countsByYear W24613772412018 @default.
- W2461377241 countsByYear W24613772412019 @default.
- W2461377241 countsByYear W24613772412020 @default.
- W2461377241 countsByYear W24613772412021 @default.
- W2461377241 countsByYear W24613772412022 @default.
- W2461377241 countsByYear W24613772412023 @default.
- W2461377241 crossrefType "journal-article" @default.
- W2461377241 hasAuthorship W2461377241A5012263073 @default.
- W2461377241 hasAuthorship W2461377241A5016888668 @default.
- W2461377241 hasAuthorship W2461377241A5026630563 @default.
- W2461377241 hasAuthorship W2461377241A5027601058 @default.
- W2461377241 hasAuthorship W2461377241A5041628351 @default.
- W2461377241 hasAuthorship W2461377241A5043385984 @default.
- W2461377241 hasAuthorship W2461377241A5048946015 @default.
- W2461377241 hasAuthorship W2461377241A5071251376 @default.
- W2461377241 hasAuthorship W2461377241A5089449964 @default.
- W2461377241 hasBestOaLocation W24613772411 @default.
- W2461377241 hasConcept C104317684 @default.
- W2461377241 hasConcept C148196450 @default.
- W2461377241 hasConcept C163949779 @default.
- W2461377241 hasConcept C196843134 @default.
- W2461377241 hasConcept C2776690073 @default.
- W2461377241 hasConcept C45413362 @default.
- W2461377241 hasConcept C54355233 @default.
- W2461377241 hasConcept C5512455 @default.
- W2461377241 hasConcept C86339819 @default.
- W2461377241 hasConcept C86803240 @default.