Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461380265> ?p ?o ?g. }
- W2461380265 abstract "Abstract Retroviral reverse transcriptase (RT) of Moloney murine leukemia virus (MoMLV) is expressed in the form of a large Gag–Pol precursor protein by suppression of translational termination in which the maximal efficiency of stop codon read-through depends on the interaction between MoMLV RT and peptidyl release factor 1 (eRF1). Here, we report the crystal structure of MoMLV RT in complex with eRF1. The MoMLV RT interacts with the C-terminal domain of eRF1 via its RNase H domain to sterically occlude the binding of peptidyl release factor 3 (eRF3) to eRF1. Promotion of read-through by MoMLV RNase H prevents nonsense-mediated mRNA decay (NMD) of mRNAs. Comparison of our structure with that of HIV RT explains why HIV RT cannot interact with eRF1. Our results provide a mechanistic view of how MoMLV manipulates the host translation termination machinery for the synthesis of its own proteins." @default.
- W2461380265 created "2016-07-22" @default.
- W2461380265 creator A5007813632 @default.
- W2461380265 creator A5031225867 @default.
- W2461380265 creator A5061822923 @default.
- W2461380265 creator A5063253432 @default.
- W2461380265 creator A5069053869 @default.
- W2461380265 creator A5073284807 @default.
- W2461380265 creator A5079284530 @default.
- W2461380265 creator A5084608734 @default.
- W2461380265 creator A5087689218 @default.
- W2461380265 date "2016-06-22" @default.
- W2461380265 modified "2023-09-24" @default.
- W2461380265 title "Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus" @default.
- W2461380265 cites W1880263903 @default.
- W2461380265 cites W1888137339 @default.
- W2461380265 cites W1914738526 @default.
- W2461380265 cites W1972855007 @default.
- W2461380265 cites W1973069601 @default.
- W2461380265 cites W1973711348 @default.
- W2461380265 cites W1983435302 @default.
- W2461380265 cites W1986191025 @default.
- W2461380265 cites W1987050385 @default.
- W2461380265 cites W1993969571 @default.
- W2461380265 cites W1995017064 @default.
- W2461380265 cites W2016765195 @default.
- W2461380265 cites W2018914487 @default.
- W2461380265 cites W2020405262 @default.
- W2461380265 cites W2022875630 @default.
- W2461380265 cites W2038276231 @default.
- W2461380265 cites W2059921194 @default.
- W2461380265 cites W2067191137 @default.
- W2461380265 cites W2075588246 @default.
- W2461380265 cites W2084836390 @default.
- W2461380265 cites W2097102109 @default.
- W2461380265 cites W2101084790 @default.
- W2461380265 cites W2102284002 @default.
- W2461380265 cites W2104825395 @default.
- W2461380265 cites W2111829379 @default.
- W2461380265 cites W2123716335 @default.
- W2461380265 cites W2124100794 @default.
- W2461380265 cites W2132153381 @default.
- W2461380265 cites W2132650893 @default.
- W2461380265 cites W2135349135 @default.
- W2461380265 cites W2139694420 @default.
- W2461380265 cites W2144081223 @default.
- W2461380265 cites W2145473270 @default.
- W2461380265 cites W2149474486 @default.
- W2461380265 cites W2153463868 @default.
- W2461380265 cites W2159006092 @default.
- W2461380265 cites W2159211495 @default.
- W2461380265 cites W2160216077 @default.
- W2461380265 cites W2167958473 @default.
- W2461380265 cites W2169652125 @default.
- W2461380265 cites W2180229411 @default.
- W2461380265 cites W2227690477 @default.
- W2461380265 cites W4248872320 @default.
- W2461380265 doi "https://doi.org/10.1038/ncomms12070" @default.
- W2461380265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4917968" @default.
- W2461380265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27329342" @default.
- W2461380265 hasPublicationYear "2016" @default.
- W2461380265 type Work @default.
- W2461380265 sameAs 2461380265 @default.
- W2461380265 citedByCount "26" @default.
- W2461380265 countsByYear W24613802652016 @default.
- W2461380265 countsByYear W24613802652017 @default.
- W2461380265 countsByYear W24613802652018 @default.
- W2461380265 countsByYear W24613802652019 @default.
- W2461380265 countsByYear W24613802652020 @default.
- W2461380265 countsByYear W24613802652021 @default.
- W2461380265 countsByYear W24613802652022 @default.
- W2461380265 countsByYear W24613802652023 @default.
- W2461380265 crossrefType "journal-article" @default.
- W2461380265 hasAuthorship W2461380265A5007813632 @default.
- W2461380265 hasAuthorship W2461380265A5031225867 @default.
- W2461380265 hasAuthorship W2461380265A5061822923 @default.
- W2461380265 hasAuthorship W2461380265A5063253432 @default.
- W2461380265 hasAuthorship W2461380265A5069053869 @default.
- W2461380265 hasAuthorship W2461380265A5073284807 @default.
- W2461380265 hasAuthorship W2461380265A5079284530 @default.
- W2461380265 hasAuthorship W2461380265A5084608734 @default.
- W2461380265 hasAuthorship W2461380265A5087689218 @default.
- W2461380265 hasBestOaLocation W24613802651 @default.
- W2461380265 hasConcept C104317684 @default.
- W2461380265 hasConcept C105580179 @default.
- W2461380265 hasConcept C10879258 @default.
- W2461380265 hasConcept C149364088 @default.
- W2461380265 hasConcept C156719811 @default.
- W2461380265 hasConcept C159047783 @default.
- W2461380265 hasConcept C20580545 @default.
- W2461380265 hasConcept C2522874641 @default.
- W2461380265 hasConcept C2779562191 @default.
- W2461380265 hasConcept C515207424 @default.
- W2461380265 hasConcept C54355233 @default.
- W2461380265 hasConcept C67705224 @default.
- W2461380265 hasConcept C69766542 @default.
- W2461380265 hasConcept C86803240 @default.
- W2461380265 hasConceptScore W2461380265C104317684 @default.
- W2461380265 hasConceptScore W2461380265C105580179 @default.
- W2461380265 hasConceptScore W2461380265C10879258 @default.