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• W2461460571 endingPage "4054" @default.
• W2461460571 startingPage "4037" @default.
• W2461460571 abstract "Filamentous fungi produce a vast array of secondary metabolites (SMs) and some play a role in agriculture or pharmacology. Sequencing of the rice pathogen Fusarium fujikuroi revealed the presence of far more SM-encoding genes than known products. SM production is energy-consuming and thus tightly regulated, leaving the majority of SM gene clusters silent under laboratory conditions. One important regulatory layer in SM biosynthesis involves histone modifications that render the underlying genes either silent or poised for transcription. Here, we show that the majority of the putative SM gene clusters in F. fujikuroi are located within facultative heterochromatin marked by trimethylated lysine 27 on histone 3 (H3K27me3). Kmt6, the methyltransferase responsible for establishing this histone mark, appears to be essential in this fungus, and knock-down of Kmt6 in the KMT6kd strain shows a drastic phenotype affecting fungal growth and development. Transcription of four so far cryptic and otherwise silent putative SM gene clusters was induced in the KMT6kd strain, in which decreased expression of KMT6 is accompanied by reduced H3K27me3 levels at the respective gene loci and accumulation of novel metabolites. One of the four putative SM gene clusters, named STC5, was analysed in more detail thereby revealing a novel sesquiterpene." @default.
• W2461460571 created "2016-07-22" @default.
• W2461460571 creator A5001277628 @default.
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• W2461460571 date "2016-07-18" @default.
• W2461460571 modified "2023-09-29" @default.
• W2461460571 title "Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in<i>Fusarium fujikuroi</i>" @default.
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• W2461460571 doi "https://doi.org/10.1111/1462-2920.13427" @default.
• W2461460571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5118082" @default.
• W2461460571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27348741" @default.
• W2461460571 hasPublicationYear "2016" @default.
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