Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461463763> ?p ?o ?g. }
- W2461463763 abstract "DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar, and singlestrand break damage resulting from oxidation, alkylation, deamination, and spontaneous hydrolysis. If left unrepaired, such lesions can become fixed in the genome as permanent mutations. Thus, evolution has led to the creation of several highly conserved, partially redundant pathways to repair or mitigate the effects of DNA base damage. The biochemical mechanisms of these pathways have been well characterized and the impact of this work was recently highlighted by the selection of Tomas Lindahl, Aziz Sancar and Paul Modrich as the recipients of the 2015 Nobel Prize in Chemistry for their seminal work in defining DNA repair pathways. However, how these repair pathways are regulated and interconnected is still being elucidated. This review focuses on the classical base excision repair and strand incision pathways in eukaryotes, considering both Saccharomyces cerevisiae and humans, and extends to some important questions and challenges facing the field of DNA base damage repair." @default.
- W2461463763 created "2016-07-22" @default.
- W2461463763 creator A5031226363 @default.
- W2461463763 creator A5076485562 @default.
- W2461463763 creator A5089604565 @default.
- W2461463763 date "2015-01-01" @default.
- W2461463763 modified "2023-09-26" @default.
- W2461463763 title "SURVEY AND SUMMARY The current state of eukaryotic DNA base damage and repair" @default.
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