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- W24615311 abstract "Each year, approximately eleven thousand new colorectal cancer (CRC) patients areregistered in the Netherlands. Half of these patients will eventually die of this disease.Consequently, it is of great importance to identify individuals with an increased risk for CRC.In this thesis, we evaluate the use of molecular pathology for identifying individualswith an increased risk for CRC based on their genetic makeup, and for generating insight into the tumorigenesis of familial CRC.We conclude that molecular pathology has a high potential for playing an active role in identifying individuals with CRC predisposing syndromes in a diagnostic setting as well as in studying tumorigenesis ofCRC in a research setting. Tests which are readily applicable and straightforward, are now extensively usedin our daily molecular pathology diagnostics. In the research setting, molecular pathology will be an important player in study the contribution to an increased CRC risk of the susceptibility alleles that are being identified. Furthermore, we now argue that the distinct tumor profiles that we found are convincing examples that molecular pathology approaches are also crucial in the characterization and elucidation of unresolved familial causes of CRC." @default.
- W24615311 created "2016-06-24" @default.
- W24615311 creator A5083205023 @default.
- W24615311 date "2008-11-27" @default.
- W24615311 modified "2023-09-27" @default.
- W24615311 title "Molecular pathology of colorectal cancer predisposing syndromes" @default.
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