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- W2461566277 abstract "Prostate cancer is a major public health concern in Australia, with around 20,000 new cases diagnosed each year. It is the most commonly diagnosed non-skin cancer in Australian men and is the second most common cause of cancer-related death in males after lung cancer. In the last decade, prostate cancer incidence rates increased dramatically, whereas mortality rates have steadily decreased ; due partly to changes in diagnostic procedures. The main risk factors for a diagnosis of prostate cancer include age and family history. Early detection is the key to enabling better outcomes and potential cure of prostate cancer. Testing blood for the presence of prostate-specific antigen (PSA), together with a digital rectal examination (DRE) offers the best opportunity to determine the presence of cancer. In Australia there is no national screening program for prostate cancer; rather it is recommended that men in high risk groups should seek voluntary annual assessments in the form of a PSA blood test and DRE. The definitive diagnosis and grading of prostatic adenocarcinoma can only be made by histopathological examination of trans-rectal ultrasound (TRUS)-guided needle prostate biopsies. The Gleason grading system offers the best indication of tumour aggressiveness. Prostatic immunohistochemistry effectively supports the microscopic diagnosis of prostatic malignancy, both primary and metastatic. Radical prostatectomy is an established surgical approach for patients with clinically localized prostate cancer. A systematic and thorough examination of a radical prostatectomy specimen gives the most accurate and detailed information available for determining prognosis and deciding on adjuvant therapy. This review focuses on the application of current laboratory practices that improve the accuracy, specificity and sensitivity of tests for the diagnosis and management of prostate cancer." @default.
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- W2461566277 date "2012-11-01" @default.
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- W2461566277 title "Current laboratory practices for the diagnosis and management of prostate cancer" @default.
- W2461566277 hasPublicationYear "2012" @default.
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