Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461567424> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2461567424 endingPage "95" @default.
- W2461567424 startingPage "389" @default.
- W2461567424 abstract "The uterine contractile response to adrenergic agonists or sympathetic stimulation is influenced dramatically by the hormonal milieu. Rabbit uterine contraction is mediated by alpha 1-adrenoceptors, whereas relaxation in response to the same stimulus is mediated by beta 2-adrenoceptors. Whether uterine contractility is increased or decreased by adrenergic stimulation is determined by the gonadal steroids estrogen and progesterone: uterine contraction prevails in the estrogen-dominant or the ovariectomized animal, but in the progesterone-dominant rabbit, uterine relaxation is observed. In previous studies, we have demonstrated that changes in the concentration or agonist affinity of these adrenoceptors cannot account for the changes in contractile response. In the present studies, we tested whether sex steroids might alter beta-adrenergic response by acting on events distal to receptor occupancy, and whether this could explain the conversion of contractile response. We found that myometrial cAMP generation is potently stimulated by beta-agonists in progesterone-treated and also in ovariectomized animals, but this stimulation is absent after estrogen treatment. Similar, but smaller, changes were observed for cAMP generation in response to prostaglandin E2 and forskolin. Stimulation of adenylate cyclase in uterine particulates by agents which act on the guanyl nucleotide-sensitive stimulatory transducer, Gs, is unchanged after estrogen treatment. However, specific labeling of Gs catalyzed by cholera toxin is reduced in membrane particulates from estrogen-treated animals. Recombination of extracts of uterine membranes from the differently treated animals also suggested qualitative differences in Gs. We conclude that at least one component of the adenylate cyclase cascade beyond the beta-adrenoceptor, i.e., Gs, is a target for ovarian steroids; estrogen reduces Gs labeling and beta-adrenoceptor-mediated cAMP production. However, uterine Gs labeling and cAMP production are similar in ovariectomized and in progesterone-treated rabbits. Since these uteri exhibit different contractile responses, the observed changes are not sufficient to explain sex steroid-mediated conversion of myometrial contractile response." @default.
- W2461567424 created "2016-07-22" @default.
- W2461567424 creator A5036215671 @default.
- W2461567424 creator A5048082438 @default.
- W2461567424 creator A5069425440 @default.
- W2461567424 creator A5070692165 @default.
- W2461567424 creator A5077449360 @default.
- W2461567424 creator A5079148010 @default.
- W2461567424 date "1988-04-01" @default.
- W2461567424 modified "2023-09-27" @default.
- W2461567424 title "Estrogen reduces beta-adrenoceptor-mediated cAMP production and the concentration of the guanyl nucleotide-regulatory protein, Gs, in rabbit myometrium." @default.
- W2461567424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2833685" @default.
- W2461567424 hasPublicationYear "1988" @default.
- W2461567424 type Work @default.
- W2461567424 sameAs 2461567424 @default.
- W2461567424 citedByCount "16" @default.
- W2461567424 crossrefType "journal-article" @default.
- W2461567424 hasAuthorship W2461567424A5036215671 @default.
- W2461567424 hasAuthorship W2461567424A5048082438 @default.
- W2461567424 hasAuthorship W2461567424A5069425440 @default.
- W2461567424 hasAuthorship W2461567424A5070692165 @default.
- W2461567424 hasAuthorship W2461567424A5077449360 @default.
- W2461567424 hasAuthorship W2461567424A5079148010 @default.
- W2461567424 hasConcept C126322002 @default.
- W2461567424 hasConcept C134018914 @default.
- W2461567424 hasConcept C170493617 @default.
- W2461567424 hasConcept C180526460 @default.
- W2461567424 hasConcept C185592680 @default.
- W2461567424 hasConcept C24998067 @default.
- W2461567424 hasConcept C2776766599 @default.
- W2461567424 hasConcept C2777006276 @default.
- W2461567424 hasConcept C2777164284 @default.
- W2461567424 hasConcept C2778164554 @default.
- W2461567424 hasConcept C2778938600 @default.
- W2461567424 hasConcept C2779066055 @default.
- W2461567424 hasConcept C2779276759 @default.
- W2461567424 hasConcept C71924100 @default.
- W2461567424 hasConcept C8264082 @default.
- W2461567424 hasConcept C86803240 @default.
- W2461567424 hasConceptScore W2461567424C126322002 @default.
- W2461567424 hasConceptScore W2461567424C134018914 @default.
- W2461567424 hasConceptScore W2461567424C170493617 @default.
- W2461567424 hasConceptScore W2461567424C180526460 @default.
- W2461567424 hasConceptScore W2461567424C185592680 @default.
- W2461567424 hasConceptScore W2461567424C24998067 @default.
- W2461567424 hasConceptScore W2461567424C2776766599 @default.
- W2461567424 hasConceptScore W2461567424C2777006276 @default.
- W2461567424 hasConceptScore W2461567424C2777164284 @default.
- W2461567424 hasConceptScore W2461567424C2778164554 @default.
- W2461567424 hasConceptScore W2461567424C2778938600 @default.
- W2461567424 hasConceptScore W2461567424C2779066055 @default.
- W2461567424 hasConceptScore W2461567424C2779276759 @default.
- W2461567424 hasConceptScore W2461567424C71924100 @default.
- W2461567424 hasConceptScore W2461567424C8264082 @default.
- W2461567424 hasConceptScore W2461567424C86803240 @default.
- W2461567424 hasIssue "4" @default.
- W2461567424 hasLocation W24615674241 @default.
- W2461567424 hasOpenAccess W2461567424 @default.
- W2461567424 hasPrimaryLocation W24615674241 @default.
- W2461567424 hasRelatedWork W1974090160 @default.
- W2461567424 hasRelatedWork W2002384464 @default.
- W2461567424 hasRelatedWork W2008205925 @default.
- W2461567424 hasRelatedWork W2017789958 @default.
- W2461567424 hasRelatedWork W2040646620 @default.
- W2461567424 hasRelatedWork W2085668963 @default.
- W2461567424 hasRelatedWork W2090136455 @default.
- W2461567424 hasRelatedWork W2108578925 @default.
- W2461567424 hasRelatedWork W2409166561 @default.
- W2461567424 hasRelatedWork W2461567424 @default.
- W2461567424 hasVolume "33" @default.
- W2461567424 isParatext "false" @default.
- W2461567424 isRetracted "false" @default.
- W2461567424 magId "2461567424" @default.
- W2461567424 workType "article" @default.