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- W2461612916 abstract "Bilirubin metabolism can schematically be considered to consist of different steps including production, transport in the blood, uptake into the cell and intracellular transport, conjugation, biliary secretion and elimination out of the body (Fig. 1). It will become clear that a disturbance in steps 1–4 will usually express itself by an unconjugated hyperbiliru-binaemia in contrast to the conjugated hyperbilirubinaemia in disorders of steps 5 and 6. Conjugation thus has a central position. Indeed, bilirubin IXα is only slightly soluble in water (Brodersen and Theilgaard, 1969). This is probably the result of bond formation hindering ionization of the carboxyl groups (Hutchinson et al., 1971)." @default.
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- W2461612916 date "1976-01-01" @default.
- W2461612916 modified "2023-09-27" @default.
- W2461612916 title "Conjugation of Bilirubin — Pathophysiological Aspects" @default.
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- W2461612916 doi "https://doi.org/10.1007/978-3-642-85451-4_114" @default.
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