Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461618802> ?p ?o ?g. }
- W2461618802 endingPage "22066" @default.
- W2461618802 startingPage "22058" @default.
- W2461618802 abstract "Over the years, several polymers have been developed for use in prosthetic heart valves as alternatives to xenografts. However, most of these materials are beset with a variety of issues, including low material strength, biodegradation, high dynamic creep, calcification, and poor hemocompatibility. We studied the mechanical, surface, and flow-mediated thrombogenic response of poly(styrene-coblock-4-vinylbenzocyclobutene)-polyisobutylene-poly(styrene-coblock-4-vinylbenzocylcobutene) (xSIBS), a thermoset version of the thermoplastic elastomeric polyolefin poly(styrene-block-isobutylene-block-styrene) (SIBS), which has been shown to be resistant to in vivo hydrolysis, oxidation, and enzymolysis. Uniaxial tensile testing yielded an ultimate tensile strength of 35 MPa, 24.5 times greater than that of SIBS. Surface analysis yielded a mean contact angle of 82.05° and surface roughness of 144 nm, which was greater than for poly(ε-caprolactone) (PCL) and poly(methyl methacrylate) (PMMA). However, the change in platelet activation state, a predictor of thrombogenicity, was not significantly different from PCL and PMMA after fluid exposure to 1 dyn/cm(2) and 20 dyn/cm(2). In addition, the number of adherent platelets after 10 dyn/cm(2) flow exposure was on the same order of magnitude as PCL and PMMA. The mechanical strength and low thrombogenicity of xSIBS therefore suggest it as a viable polymeric substrate for fabrication of prosthetic heart valves and other cardiovascular devices." @default.
- W2461618802 created "2016-07-22" @default.
- W2461618802 creator A5007727015 @default.
- W2461618802 creator A5011018910 @default.
- W2461618802 creator A5025384321 @default.
- W2461618802 creator A5032983062 @default.
- W2461618802 creator A5034094116 @default.
- W2461618802 creator A5045882196 @default.
- W2461618802 creator A5051249259 @default.
- W2461618802 creator A5070730048 @default.
- W2461618802 creator A5079570118 @default.
- W2461618802 date "2015-09-23" @default.
- W2461618802 modified "2023-10-01" @default.
- W2461618802 title "Physical Characterization and Platelet Interactions under Shear Flows of a Novel Thermoset Polyisobutylene-based Co-polymer" @default.
- W2461618802 cites W17142061 @default.
- W2461618802 cites W1766678233 @default.
- W2461618802 cites W1956031558 @default.
- W2461618802 cites W1964642897 @default.
- W2461618802 cites W1969720022 @default.
- W2461618802 cites W1977061239 @default.
- W2461618802 cites W1977890191 @default.
- W2461618802 cites W1980077371 @default.
- W2461618802 cites W1984418916 @default.
- W2461618802 cites W1991065054 @default.
- W2461618802 cites W1992721237 @default.
- W2461618802 cites W1994494585 @default.
- W2461618802 cites W2004877339 @default.
- W2461618802 cites W2006162783 @default.
- W2461618802 cites W2013048165 @default.
- W2461618802 cites W2015886368 @default.
- W2461618802 cites W2019990226 @default.
- W2461618802 cites W2021540155 @default.
- W2461618802 cites W2022971200 @default.
- W2461618802 cites W2024881611 @default.
- W2461618802 cites W2025395243 @default.
- W2461618802 cites W2026511177 @default.
- W2461618802 cites W2031722693 @default.
- W2461618802 cites W2036229179 @default.
- W2461618802 cites W2037368902 @default.
- W2461618802 cites W2039205501 @default.
- W2461618802 cites W2039817227 @default.
- W2461618802 cites W2040302813 @default.
- W2461618802 cites W2044147390 @default.
- W2461618802 cites W2048539964 @default.
- W2461618802 cites W2051288112 @default.
- W2461618802 cites W2053088455 @default.
- W2461618802 cites W2054265385 @default.
- W2461618802 cites W2054651797 @default.
- W2461618802 cites W2054747826 @default.
- W2461618802 cites W2060872636 @default.
- W2461618802 cites W2062681608 @default.
- W2461618802 cites W2065147016 @default.
- W2461618802 cites W2074614365 @default.
- W2461618802 cites W2083804937 @default.
- W2461618802 cites W2086757346 @default.
- W2461618802 cites W2087699353 @default.
- W2461618802 cites W2088778717 @default.
- W2461618802 cites W2091541691 @default.
- W2461618802 cites W2095016677 @default.
- W2461618802 cites W2095156095 @default.
- W2461618802 cites W2106615427 @default.
- W2461618802 cites W2107926535 @default.
- W2461618802 cites W2111664167 @default.
- W2461618802 cites W2119286443 @default.
- W2461618802 cites W2119380315 @default.
- W2461618802 cites W2119487205 @default.
- W2461618802 cites W2119884676 @default.
- W2461618802 cites W2121956182 @default.
- W2461618802 cites W2129447163 @default.
- W2461618802 cites W2132597857 @default.
- W2461618802 cites W2137719165 @default.
- W2461618802 cites W2138419890 @default.
- W2461618802 cites W2139944170 @default.
- W2461618802 cites W2142172856 @default.
- W2461618802 cites W2149790596 @default.
- W2461618802 cites W2155457802 @default.
- W2461618802 cites W2160616952 @default.
- W2461618802 cites W2161256499 @default.
- W2461618802 cites W2162079984 @default.
- W2461618802 cites W2164788252 @default.
- W2461618802 cites W2165452432 @default.
- W2461618802 cites W2165754900 @default.
- W2461618802 cites W2186452413 @default.
- W2461618802 cites W2409287651 @default.
- W2461618802 cites W2417248918 @default.
- W2461618802 cites W97201516 @default.
- W2461618802 doi "https://doi.org/10.1021/acsami.5b07254" @default.
- W2461618802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4608843" @default.
- W2461618802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26398588" @default.
- W2461618802 hasPublicationYear "2015" @default.
- W2461618802 type Work @default.
- W2461618802 sameAs 2461618802 @default.
- W2461618802 citedByCount "18" @default.
- W2461618802 countsByYear W24616188022016 @default.
- W2461618802 countsByYear W24616188022017 @default.
- W2461618802 countsByYear W24616188022018 @default.
- W2461618802 countsByYear W24616188022019 @default.
- W2461618802 countsByYear W24616188022020 @default.