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• W2461699238 abstract "Bastimolide A (1), a polyhydroxy macrolide with a 40-membered ring, was isolated from a new genus of the tropical marine cyanobacterium Okeania hirsuta. This novel macrolide was defined by spectroscopy and chemical reactions to possess one 1,3-diol, one 1,3,5-triol, six 1,5-diols, and one tert-butyl group; however, the relationships of these moieties to one another were obscured by a highly degenerate (1)H NMR spectrum. Its complete structure and absolute configuration were therefore unambiguously determined by X-ray diffraction analysis of the nona-p-nitrobenzoate derivative (1d). Pure bastimolide A (1) showed potent antimalarial activity against four resistant strains of Plasmodium falciparum with IC50 values between 80 and 270 nM, although with some toxicity to the control Vero cells (IC50 = 2.1 μM), and thus represents a potentially promising lead for antimalarial drug discovery. Moreover, rigorous establishment of its molecular arrangement gives fresh insight into the structures and biosynthesis of cyanobacterial polyhydroxymacrolides." @default.
• W2461699238 created "2016-07-22" @default.
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• W2461699238 date "2015-08-05" @default.
• W2461699238 modified "2023-10-17" @default.
• W2461699238 title "Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium <i>Okeania hirsuta</i>" @default.
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• W2461699238 doi "https://doi.org/10.1021/acs.joc.5b01264" @default.
• W2461699238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26222145" @default.
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