FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461708130> ?p ?o ?g. }

• W2461708130 endingPage "1276" @default.
• W2461708130 startingPage "1268" @default.
• W2461708130 abstract "Abstract Diabetic retinopathy (DR) is the leading cause of blindness in working-age people. Pericyte loss is one of the pathologic cellular events in DR, which weakens the retinal microvessels. Damage to the microvascular networks is irreversible and permanent; thus further progression of DR is inevitable. In this study, we hypothesize that multipotent perivascular progenitor cells derived from human embryonic stem cells (hESC-PVPCs) improve the damaged retinal vasculature in the streptozotocin-induced diabetic rodent models. We describe a highly efficient and feasible protocol to derive such cells with a natural selection method without cell-sorting processes. As a cellular model of pericytes, hESC-PVPCs exhibited marker expressions such as CD140B, CD146, NG2, and functional characteristics of pericytes. Following a single intravitreal injection into diabetic Brown Norway rats, we demonstrate that the cells localized alongside typical perivascular regions of the retinal vasculature and stabilized the blood-retinal barrier breakdown. Findings in this study highlight a therapeutic potential of hESC-PVPCs in DR by mimicking the role of pericytes in vascular stabilization. Significance This study provides a simple and feasible method to generate perivascular progenitor cells from human embryonic stem cells. These cells share functional characteristics with pericytes, which are irreversibly lost at the onset of diabetic retinopathy. Animal studies demonstrated that replenishing the damaged pericytes with perivascular progenitor cells could restore retinal vascular integrity and prevent fluid leakage. This provides promising and compelling evidence that perivascular progenitor cells can be used as a novel therapeutic agent to treat diabetic retinopathy patients." @default.
• W2461708130 created "2016-07-22" @default.
• W2461708130 creator A5002662560 @default.
• W2461708130 creator A5017004820 @default.
• W2461708130 creator A5026038695 @default.
• W2461708130 creator A5028411609 @default.
• W2461708130 creator A5053147575 @default.
• W2461708130 creator A5054893659 @default.
• W2461708130 creator A5065645577 @default.
• W2461708130 date "2016-07-07" @default.
• W2461708130 modified "2023-09-23" @default.
• W2461708130 title "Perivascular Progenitor Cells Derived From Human Embryonic Stem Cells Exhibit Functional Characteristics of Pericytes and Improve the Retinal Vasculature in a Rodent Model of Diabetic Retinopathy" @default.
• W2461708130 cites W1497501897 @default.
• W2461708130 cites W1588633184 @default.
• W2461708130 cites W1968221108 @default.
• W2461708130 cites W1976857084 @default.
• W2461708130 cites W1982694306 @default.
• W2461708130 cites W1990136121 @default.
• W2461708130 cites W1990493390 @default.
• W2461708130 cites W1995830850 @default.
• W2461708130 cites W2002045948 @default.
• W2461708130 cites W2006712783 @default.
• W2461708130 cites W2009206983 @default.
• W2461708130 cites W2026684656 @default.
• W2461708130 cites W2027111051 @default.
• W2461708130 cites W2033766261 @default.
• W2461708130 cites W2062648563 @default.
• W2461708130 cites W2069590633 @default.
• W2461708130 cites W2073290778 @default.
• W2461708130 cites W2076491580 @default.
• W2461708130 cites W2083542458 @default.
• W2461708130 cites W2086706252 @default.
• W2461708130 cites W2086914356 @default.
• W2461708130 cites W2092882523 @default.
• W2461708130 cites W2094935740 @default.
• W2461708130 cites W2094960653 @default.
• W2461708130 cites W2096145966 @default.
• W2461708130 cites W2097938259 @default.
• W2461708130 cites W2099204208 @default.
• W2461708130 cites W2110002598 @default.
• W2461708130 cites W2132040456 @default.
• W2461708130 cites W2155580843 @default.
• W2461708130 cites W85640122 @default.
• W2461708130 doi "https://doi.org/10.5966/sctm.2015-0342" @default.
• W2461708130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4996442" @default.
• W2461708130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27388242" @default.
• W2461708130 hasPublicationYear "2016" @default.
• W2461708130 type Work @default.
• W2461708130 sameAs 2461708130 @default.
• W2461708130 citedByCount "37" @default.
• W2461708130 countsByYear W24617081302017 @default.
• W2461708130 countsByYear W24617081302018 @default.
• W2461708130 countsByYear W24617081302019 @default.
• W2461708130 countsByYear W24617081302020 @default.
• W2461708130 countsByYear W24617081302021 @default.
• W2461708130 countsByYear W24617081302022 @default.
• W2461708130 countsByYear W24617081302023 @default.
• W2461708130 crossrefType "journal-article" @default.
• W2461708130 hasAuthorship W2461708130A5002662560 @default.
• W2461708130 hasAuthorship W2461708130A5017004820 @default.
• W2461708130 hasAuthorship W2461708130A5026038695 @default.
• W2461708130 hasAuthorship W2461708130A5028411609 @default.
• W2461708130 hasAuthorship W2461708130A5053147575 @default.
• W2461708130 hasAuthorship W2461708130A5054893659 @default.
• W2461708130 hasAuthorship W2461708130A5065645577 @default.
• W2461708130 hasBestOaLocation W24617081301 @default.
• W2461708130 hasConcept C10205521 @default.
• W2461708130 hasConcept C104317684 @default.
• W2461708130 hasConcept C123012128 @default.
• W2461708130 hasConcept C134018914 @default.
• W2461708130 hasConcept C142724271 @default.
• W2461708130 hasConcept C145103041 @default.
• W2461708130 hasConcept C169760540 @default.
• W2461708130 hasConcept C201750760 @default.
• W2461708130 hasConcept C202751555 @default.
• W2461708130 hasConcept C2777093970 @default.
• W2461708130 hasConcept C2778371105 @default.
• W2461708130 hasConcept C2779093498 @default.
• W2461708130 hasConcept C2779829184 @default.
• W2461708130 hasConcept C2780427682 @default.
• W2461708130 hasConcept C2780827179 @default.
• W2461708130 hasConcept C28328180 @default.
• W2461708130 hasConcept C55493867 @default.
• W2461708130 hasConcept C555293320 @default.
• W2461708130 hasConcept C71924100 @default.
• W2461708130 hasConcept C86803240 @default.
• W2461708130 hasConcept C95444343 @default.
• W2461708130 hasConceptScore W2461708130C10205521 @default.
• W2461708130 hasConceptScore W2461708130C104317684 @default.
• W2461708130 hasConceptScore W2461708130C123012128 @default.
• W2461708130 hasConceptScore W2461708130C134018914 @default.
• W2461708130 hasConceptScore W2461708130C142724271 @default.
• W2461708130 hasConceptScore W2461708130C145103041 @default.
• W2461708130 hasConceptScore W2461708130C169760540 @default.
• W2461708130 hasConceptScore W2461708130C201750760 @default.
• W2461708130 hasConceptScore W2461708130C202751555 @default.
• W2461708130 hasConceptScore W2461708130C2777093970 @default.
• W2461708130 hasConceptScore W2461708130C2778371105 @default.

• next