Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461732382> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2461732382 endingPage "e000381" @default.
- W2461732382 startingPage "e000381" @default.
- W2461732382 abstract "<h3>Objectives</h3> To explore potential mechanisms that underpin the cardiac abnormalities seen in chronic fatigue syndrome (CFS) using non-invasive cardiac impedance, red cell mass and plasma volume measurements. <h3>Methods</h3> Cardiac MR (MR) examinations were performed using 3 T Philips Intera Achieva scanner (Best, NL) in participants with CFS (Fukuda; n=47) and matched case-by-case controls. Total volume (TV), red cell volume (RCV) and plasma volume (PV) measurements were performed (41 CFS and 10 controls) using the indicator dilution technique using simultaneous 51-chromium labelling of red blood cells and 125-iodine labelling of serum albumin. <h3>Results</h3> The CFS group length of history (mean±SD) was 14±10 years. Patients with CFS had significantly reduced end-systolic and end-diastolic volumes together with reduced end-diastolic wall masses (all p<0.0001). Mean±SD RCV was 1565±443 mL with 26/41 (63%) having values below 95% of expected. PV was 2659±529 mL with 13/41 (32%) <95% expected. There were strong positive correlations between TV, RCV and PV and cardiac end-diastolic wall mass (all p<0.0001; r<sup>2</sup>=0.5). Increasing fatigue severity correlated negatively with lower PV (p=0.04; r<sup>2</sup>=0.2). There were no relationships between any MR or volume measurements and length of history, suggesting that deconditioning was unlikely to be the cause of these abnormalities. <h3>Conclusions</h3> This study confirms an association between reduced cardiac volumes and blood volume in CFS. Lack of relationship between length of disease, cardiac and plasma volumes suggests findings are not secondary to deconditioning. The relationship between plasma volume and severity of fatigue symptoms suggests a potential therapeutic target in CFS." @default.
- W2461732382 created "2016-07-22" @default.
- W2461732382 creator A5000136849 @default.
- W2461732382 creator A5039279228 @default.
- W2461732382 creator A5041763919 @default.
- W2461732382 creator A5046225534 @default.
- W2461732382 creator A5073494425 @default.
- W2461732382 creator A5082915677 @default.
- W2461732382 creator A5084897291 @default.
- W2461732382 creator A5091502124 @default.
- W2461732382 date "2016-06-01" @default.
- W2461732382 modified "2023-10-17" @default.
- W2461732382 title "Reduced cardiac volumes in chronic fatigue syndrome associate with plasma volume but not length of disease: a cohort study" @default.
- W2461732382 cites W1575162641 @default.
- W2461732382 cites W1971295110 @default.
- W2461732382 cites W1978003440 @default.
- W2461732382 cites W1978692378 @default.
- W2461732382 cites W2000231389 @default.
- W2461732382 cites W2034199186 @default.
- W2461732382 cites W2060263623 @default.
- W2461732382 cites W2066093376 @default.
- W2461732382 cites W2088938749 @default.
- W2461732382 cites W2091610180 @default.
- W2461732382 cites W2098287790 @default.
- W2461732382 cites W2098839916 @default.
- W2461732382 cites W2108230902 @default.
- W2461732382 cites W2119431303 @default.
- W2461732382 cites W2143180730 @default.
- W2461732382 cites W2189186190 @default.
- W2461732382 doi "https://doi.org/10.1136/openhrt-2015-000381" @default.
- W2461732382 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4932290" @default.
- W2461732382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27403329" @default.
- W2461732382 hasPublicationYear "2016" @default.
- W2461732382 type Work @default.
- W2461732382 sameAs 2461732382 @default.
- W2461732382 citedByCount "14" @default.
- W2461732382 countsByYear W24617323822016 @default.
- W2461732382 countsByYear W24617323822017 @default.
- W2461732382 countsByYear W24617323822018 @default.
- W2461732382 countsByYear W24617323822019 @default.
- W2461732382 countsByYear W24617323822020 @default.
- W2461732382 countsByYear W24617323822021 @default.
- W2461732382 countsByYear W24617323822022 @default.
- W2461732382 countsByYear W24617323822023 @default.
- W2461732382 crossrefType "journal-article" @default.
- W2461732382 hasAuthorship W2461732382A5000136849 @default.
- W2461732382 hasAuthorship W2461732382A5039279228 @default.
- W2461732382 hasAuthorship W2461732382A5041763919 @default.
- W2461732382 hasAuthorship W2461732382A5046225534 @default.
- W2461732382 hasAuthorship W2461732382A5073494425 @default.
- W2461732382 hasAuthorship W2461732382A5082915677 @default.
- W2461732382 hasAuthorship W2461732382A5084897291 @default.
- W2461732382 hasAuthorship W2461732382A5091502124 @default.
- W2461732382 hasBestOaLocation W24617323821 @default.
- W2461732382 hasConcept C126322002 @default.
- W2461732382 hasConcept C164705383 @default.
- W2461732382 hasConcept C24595384 @default.
- W2461732382 hasConcept C2778198053 @default.
- W2461732382 hasConcept C2779566273 @default.
- W2461732382 hasConcept C2991747820 @default.
- W2461732382 hasConcept C57900726 @default.
- W2461732382 hasConcept C71924100 @default.
- W2461732382 hasConcept C84393581 @default.
- W2461732382 hasConceptScore W2461732382C126322002 @default.
- W2461732382 hasConceptScore W2461732382C164705383 @default.
- W2461732382 hasConceptScore W2461732382C24595384 @default.
- W2461732382 hasConceptScore W2461732382C2778198053 @default.
- W2461732382 hasConceptScore W2461732382C2779566273 @default.
- W2461732382 hasConceptScore W2461732382C2991747820 @default.
- W2461732382 hasConceptScore W2461732382C57900726 @default.
- W2461732382 hasConceptScore W2461732382C71924100 @default.
- W2461732382 hasConceptScore W2461732382C84393581 @default.
- W2461732382 hasFunder F4320334626 @default.
- W2461732382 hasIssue "1" @default.
- W2461732382 hasLocation W24617323821 @default.
- W2461732382 hasLocation W24617323822 @default.
- W2461732382 hasLocation W24617323823 @default.
- W2461732382 hasLocation W24617323824 @default.
- W2461732382 hasLocation W24617323825 @default.
- W2461732382 hasOpenAccess W2461732382 @default.
- W2461732382 hasPrimaryLocation W24617323821 @default.
- W2461732382 hasRelatedWork W1531601525 @default.
- W2461732382 hasRelatedWork W1996744115 @default.
- W2461732382 hasRelatedWork W2003275267 @default.
- W2461732382 hasRelatedWork W2057135676 @default.
- W2461732382 hasRelatedWork W2064569258 @default.
- W2461732382 hasRelatedWork W2428188896 @default.
- W2461732382 hasRelatedWork W3173606202 @default.
- W2461732382 hasRelatedWork W3183948672 @default.
- W2461732382 hasRelatedWork W2778153218 @default.
- W2461732382 hasRelatedWork W3110381201 @default.
- W2461732382 hasVolume "3" @default.
- W2461732382 isParatext "false" @default.
- W2461732382 isRetracted "false" @default.
- W2461732382 magId "2461732382" @default.
- W2461732382 workType "article" @default.