Matches in SemOpenAlex for { <https://semopenalex.org/work/W2461794325> ?p ?o ?g. }
- W2461794325 endingPage "29" @default.
- W2461794325 startingPage "1" @default.
- W2461794325 abstract "Defects of the cornea play an important role in clinical genetics, because abnormalities are often easily detected on clinical ophthalmic examination. This allows for efficient screening, phenotypic categorization, and correlation with molecular genetic findings. Corneal dystrophies tend to be autosomal dominant, bilateral, not usually associated with other ocular or systemic abnormalities, are often limited to a single corneal layer, commonly involve the central cornea, and progress with time. Many dystrophies display genetic heterogeneity and/or phenotypic variability. Recent discoveries of genetic defects have enhanced our understanding of several dystrophies and allowed for more accurate classification. Keratoconus displays a conical protrusion of the cornea associated with central stromal thinning and irregularity of the corneal surface. Its pathogenesis is unknown and no candidate gene has been identified. Newer treatment options have shown promise. Metabolic disorders are generally associated with accumulation of an abnormal substance in the cornea. If the substance is produced by the cornea, it can appear throughout it. If it is elevated in the blood, it tends to accumulate in the corneal periphery. Inherited corneal defects can occur as isolated findings and in association with systemic disease. Awareness of corneal disorders is important to general physicians, geneticists and ophthalmologists." @default.
- W2461794325 created "2016-07-22" @default.
- W2461794325 creator A5034648190 @default.
- W2461794325 creator A5048453659 @default.
- W2461794325 creator A5058999141 @default.
- W2461794325 date "2013-01-01" @default.
- W2461794325 modified "2023-10-18" @default.
- W2461794325 title "Defects of the Cornea" @default.
- W2461794325 cites W117408561 @default.
- W2461794325 cites W127163929 @default.
- W2461794325 cites W1499107972 @default.
- W2461794325 cites W1561649047 @default.
- W2461794325 cites W1569285898 @default.
- W2461794325 cites W1577831380 @default.
- W2461794325 cites W1583766459 @default.
- W2461794325 cites W1769724141 @default.
- W2461794325 cites W1964057962 @default.
- W2461794325 cites W1964348818 @default.
- W2461794325 cites W1964685140 @default.
- W2461794325 cites W1964795910 @default.
- W2461794325 cites W1966378075 @default.
- W2461794325 cites W1967078857 @default.
- W2461794325 cites W1967465024 @default.
- W2461794325 cites W1967974574 @default.
- W2461794325 cites W1969600916 @default.
- W2461794325 cites W1970715106 @default.
- W2461794325 cites W1973516953 @default.
- W2461794325 cites W1974031495 @default.
- W2461794325 cites W1974311924 @default.
- W2461794325 cites W1976838262 @default.
- W2461794325 cites W1977734316 @default.
- W2461794325 cites W1981521582 @default.
- W2461794325 cites W1982081156 @default.
- W2461794325 cites W1982129684 @default.
- W2461794325 cites W1982582544 @default.
- W2461794325 cites W1983163800 @default.
- W2461794325 cites W1985424710 @default.
- W2461794325 cites W1985695558 @default.
- W2461794325 cites W1987570103 @default.
- W2461794325 cites W1988619572 @default.
- W2461794325 cites W1988670281 @default.
- W2461794325 cites W1989547479 @default.
- W2461794325 cites W1990505281 @default.
- W2461794325 cites W1991409526 @default.
- W2461794325 cites W1992511977 @default.
- W2461794325 cites W1992987620 @default.
- W2461794325 cites W1993655702 @default.
- W2461794325 cites W1993893114 @default.
- W2461794325 cites W1993914719 @default.
- W2461794325 cites W1995548119 @default.
- W2461794325 cites W1996392519 @default.
- W2461794325 cites W1996544912 @default.
- W2461794325 cites W1996775775 @default.
- W2461794325 cites W1997105607 @default.
- W2461794325 cites W1997666364 @default.
- W2461794325 cites W1997926601 @default.
- W2461794325 cites W1999312298 @default.
- W2461794325 cites W2000544973 @default.
- W2461794325 cites W2001715553 @default.
- W2461794325 cites W2003221000 @default.
- W2461794325 cites W2003994887 @default.
- W2461794325 cites W2004185111 @default.
- W2461794325 cites W2006750590 @default.
- W2461794325 cites W2007014807 @default.
- W2461794325 cites W2007584405 @default.
- W2461794325 cites W2008140742 @default.
- W2461794325 cites W2008247935 @default.
- W2461794325 cites W2008339671 @default.
- W2461794325 cites W2008853000 @default.
- W2461794325 cites W2009035684 @default.
- W2461794325 cites W2012161417 @default.
- W2461794325 cites W2012725375 @default.
- W2461794325 cites W2012982927 @default.
- W2461794325 cites W2013536618 @default.
- W2461794325 cites W2015311268 @default.
- W2461794325 cites W2017862651 @default.
- W2461794325 cites W2018621238 @default.
- W2461794325 cites W2020033177 @default.
- W2461794325 cites W2020375142 @default.
- W2461794325 cites W2020675229 @default.
- W2461794325 cites W2021007664 @default.
- W2461794325 cites W2021753849 @default.
- W2461794325 cites W2023744385 @default.
- W2461794325 cites W2024694607 @default.
- W2461794325 cites W2025471951 @default.
- W2461794325 cites W2028701027 @default.
- W2461794325 cites W2029165653 @default.
- W2461794325 cites W2029759984 @default.
- W2461794325 cites W2029937698 @default.
- W2461794325 cites W2031998212 @default.
- W2461794325 cites W2036207607 @default.
- W2461794325 cites W2036574611 @default.
- W2461794325 cites W2038838247 @default.
- W2461794325 cites W2039085437 @default.
- W2461794325 cites W2039598802 @default.
- W2461794325 cites W2041098234 @default.
- W2461794325 cites W2041612214 @default.
- W2461794325 cites W2044332662 @default.