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• W2461877118 startingPage "719" @default.
• W2461877118 abstract "Seasonal changes in environmental conditions are accompanied by significant adjustment of multiple biological processes. In temperate regions, the day fraction, or photoperiod, is a robust environmental cue that synchronizes seasonal variations in neuroendocrine and metabolic function. In this work, we propose a semimechanistic mathematical model that considers the influence of seasonal photoperiod changes as well as cellular and molecular adaptations to investigate the seasonality of immune function. Our model predicts that the circadian rhythms of cortisol, our proinflammatory mediator, and its receptor exhibit seasonal differences in amplitude and phase, oscillating at higher amplitudes in the winter season with peak times occurring later in the day. Furthermore, the reduced photoperiod of winter coupled with seasonal alterations in physiological activity induces a more exacerbated immune response to acute stress, simulated in our studies as the administration of an acute dose of endotoxin. Our findings are therefore in accordance with experimental data that reflect the predominance of a proinflammatory state during the winter months. These changes in circadian rhythm dynamics may play a significant role in the seasonality of disease incidence and regulate the diurnal and seasonal variation of disease symptom severity." @default.
• W2461877118 created "2016-07-22" @default.
• W2461877118 creator A5044946973 @default.
• W2461877118 creator A5049184270 @default.
• W2461877118 creator A5079307634 @default.
• W2461877118 date "2016-10-01" @default.
• W2461877118 modified "2023-10-16" @default.
• W2461877118 title "The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity" @default.
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