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• W2461901214 endingPage "C331" @default.
• W2461901214 startingPage "C319" @default.
• W2461901214 abstract "Human airway epithelia are predominantly Na(+)-absorbing epithelia. To investigate the mechanisms for Na+ absorption across airway epithelia, the driving forces and paths for Na+ translocation across each membrane were examined with double-barreled Na(+)-selective microelectrodes in cultured human nasal epithelium (HNE). Under control conditions, intracellular Na+ activity (acNa) was 23 +/- 1 mM (n = 44 preparations, 393 impalements). Amiloride (10(-4) M) hyperpolarized the apical membrane and increased the fractional apical membrane resistance but did not affect acNa. Exposure to Na(+)-free luminal solution induced bioelectric responses similar to amiloride but also reduced acNa to 8 +/- 1 mM. Reduction of luminal Na+ concentration ([Na+]) in the presence of amiloride also reduced acNa without further changes in bioelectric parameters. Reduction of serosal [Na+] decreased aNac, a response blocked by bumetanide (10(-4) M). Ouabain (10(-4) M, serosal) led to a reduction in equivalent short-circuit current (Ieq) and increase in acNa. We conclude that 1) acNa is higher in HNE than in most mammalian epithelial cells, 2) the apical membrane expresses a conductive Na+ path, and 3) the basolateral membrane transports Na+ via the Na(+)-K(+)-adenosinetriphosphatase and a Na(+)-K(+)-2Cl- cotransport system." @default.
• W2461901214 created "2016-07-22" @default.
• W2461901214 creator A5001166056 @default.
• W2461901214 creator A5074871331 @default.
• W2461901214 date "1991-08-01" @default.
• W2461901214 modified "2023-10-15" @default.
• W2461901214 title "Sodium transport and intracellular sodium activity in cultured human nasal epithelium" @default.
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• W2461901214 doi "https://doi.org/10.1152/ajpcell.1991.261.2.c319" @default.
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