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- W2461940749 endingPage "749" @default.
- W2461940749 startingPage "734" @default.
- W2461940749 abstract "The injectisome type three secretion system (T3SS) is a major virulence factor in Pseudomonas aeruginosa. This bacterium is responsible for severe infections in immunosuppressed or cystic fibrosis patients and has become resistant to many antibiotics. Inhibitors of T3SS may therefore constitute an innovative therapeutic target. After a brief description of the T3SS and its regulation, this review presents strategies to inhibit T3SS-mediated toxicity and describes the main families of existing inhibitors. Over the past few years, 12 classes of small-molecule inhibitors and two types of antibody have been discovered and evaluated in vitro for their capacity to inhibit T3SS expression or function, and to protect host cells from T3SS-mediated cytotoxicity. While only one small molecule has been tested in vivo, a bifunctional antibody targeting both the translocation apparatus of the T3SS and a surface polysaccharide is currently in Phase II clinical trials." @default.
- W2461940749 created "2016-07-22" @default.
- W2461940749 creator A5008630212 @default.
- W2461940749 creator A5019102142 @default.
- W2461940749 creator A5060079116 @default.
- W2461940749 date "2016-09-01" @default.
- W2461940749 modified "2023-10-17" @default.
- W2461940749 title "Targeting the Type Three Secretion System in Pseudomonas aeruginosa" @default.
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- W2461940749 doi "https://doi.org/10.1016/j.tips.2016.05.011" @default.
- W2461940749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27344210" @default.
- W2461940749 hasPublicationYear "2016" @default.
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