Matches in SemOpenAlex for { <https://semopenalex.org/work/W2462022051> ?p ?o ?g. }
- W2462022051 abstract "Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Survivin is also distinctive; it is prominently expressed during embryonal development, absent in most normal, terminally differentiated tissues but upregulated in a variety of human cancers. Expression of Survivin in tumours correlates with not only inhibition of apoptosis and a decreased rate of cell death, but also resistance to chemotherapy and aggressiveness of tumours. Therefore, Survivin is an important target for cancer vaccines and therapeutics. Survivin has also been found to be prominently expressed on both human and embryonic stem cells and many somatic stem cell types indicating its yet unexplored role in stem cell generation and maintenance. Overall, Survivin emerges as a molecule with much wider role in cellular homeostasis. This review will discuss various aspects of Survivin biology and its role in regulation of apoptosis, cell division, chemo-resistance and tumour progression. Various molecular and immunotherapeutic approaches targeting Survivin will also be discussed." @default.
- W2462022051 created "2016-07-22" @default.
- W2462022051 creator A5019452347 @default.
- W2462022051 creator A5029756366 @default.
- W2462022051 creator A5037578745 @default.
- W2462022051 creator A5073728973 @default.
- W2462022051 creator A5081471159 @default.
- W2462022051 date "2016-06-23" @default.
- W2462022051 modified "2023-10-13" @default.
- W2462022051 title "Survivin: a unique target for tumor therapy" @default.
- W2462022051 cites W147472336 @default.
- W2462022051 cites W1492587973 @default.
- W2462022051 cites W1510865194 @default.
- W2462022051 cites W1519403813 @default.
- W2462022051 cites W1523461418 @default.
- W2462022051 cites W1535874622 @default.
- W2462022051 cites W1549487237 @default.
- W2462022051 cites W1557686543 @default.
- W2462022051 cites W1595083214 @default.
- W2462022051 cites W1602732985 @default.
- W2462022051 cites W1757111527 @default.
- W2462022051 cites W1768187423 @default.
- W2462022051 cites W1885114449 @default.
- W2462022051 cites W1917962573 @default.
- W2462022051 cites W1930737617 @default.
- W2462022051 cites W1944833403 @default.
- W2462022051 cites W1961680179 @default.
- W2462022051 cites W1961949729 @default.
- W2462022051 cites W1964778579 @default.
- W2462022051 cites W1965336678 @default.
- W2462022051 cites W1965695827 @default.
- W2462022051 cites W1969075574 @default.
- W2462022051 cites W1969796729 @default.
- W2462022051 cites W1970420774 @default.
- W2462022051 cites W1970445062 @default.
- W2462022051 cites W1971487741 @default.
- W2462022051 cites W1972050530 @default.
- W2462022051 cites W1973300532 @default.
- W2462022051 cites W1976457595 @default.
- W2462022051 cites W1978860647 @default.
- W2462022051 cites W1982013078 @default.
- W2462022051 cites W1982554619 @default.
- W2462022051 cites W1983312081 @default.
- W2462022051 cites W1983838537 @default.
- W2462022051 cites W1985068997 @default.
- W2462022051 cites W1986048086 @default.
- W2462022051 cites W1986899689 @default.
- W2462022051 cites W1989394815 @default.
- W2462022051 cites W1990841196 @default.
- W2462022051 cites W1992892839 @default.
- W2462022051 cites W1994547407 @default.
- W2462022051 cites W1995194683 @default.
- W2462022051 cites W1996346417 @default.
- W2462022051 cites W1998681197 @default.
- W2462022051 cites W1999660608 @default.
- W2462022051 cites W2002154440 @default.
- W2462022051 cites W2003729867 @default.
- W2462022051 cites W2004758839 @default.
- W2462022051 cites W2005727584 @default.
- W2462022051 cites W2005742227 @default.
- W2462022051 cites W2005846325 @default.
- W2462022051 cites W2009477693 @default.
- W2462022051 cites W2010831478 @default.
- W2462022051 cites W2013801793 @default.
- W2462022051 cites W2015446910 @default.
- W2462022051 cites W2016537711 @default.
- W2462022051 cites W2022717756 @default.
- W2462022051 cites W2026208664 @default.
- W2462022051 cites W2026741333 @default.
- W2462022051 cites W2026865652 @default.
- W2462022051 cites W2031424456 @default.
- W2462022051 cites W2035309395 @default.
- W2462022051 cites W2035523654 @default.
- W2462022051 cites W2038207065 @default.
- W2462022051 cites W2038465110 @default.
- W2462022051 cites W2038901717 @default.
- W2462022051 cites W2042572261 @default.
- W2462022051 cites W2044034913 @default.
- W2462022051 cites W2044459199 @default.
- W2462022051 cites W2047392100 @default.
- W2462022051 cites W2050435702 @default.
- W2462022051 cites W2052098111 @default.
- W2462022051 cites W2053029599 @default.
- W2462022051 cites W2053844022 @default.
- W2462022051 cites W2056193170 @default.
- W2462022051 cites W2056371902 @default.
- W2462022051 cites W2058115449 @default.
- W2462022051 cites W2060076339 @default.
- W2462022051 cites W2062126509 @default.
- W2462022051 cites W2062254683 @default.
- W2462022051 cites W2066441074 @default.
- W2462022051 cites W2066671159 @default.
- W2462022051 cites W2067118877 @default.
- W2462022051 cites W2068323100 @default.
- W2462022051 cites W2074919423 @default.
- W2462022051 cites W2077918967 @default.
- W2462022051 cites W2080156046 @default.
- W2462022051 cites W2080924552 @default.
- W2462022051 cites W2081933521 @default.
- W2462022051 cites W2081934185 @default.