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• W2462108915 abstract "ABSTRACTPurpose: Since some studies have reported differences in the association of age-related macular degeneration (AMD) with biological sex, we set out to determine whether the difference in the disease susceptibility is afforded by common single nucleotide polymorphisms (SNPs) associated with AMD.Methods: We genotyped 2067 Caucasian subjects from the Age-Related Eye Disease Study cohort for commonly associated AMD SNPs, including those in CFH (rs1061170, rs1410996, and rs3766404), ARMS2 (rs10490924), and C3 (rs2230199) using either a Sequenom MassARRAY MALDI-TOF mass spectrometer or using Taqman genotyping reagents. A Cox proportional hazards model was used to determine the effect of genotype, age, sex, and smoking status on the development of AMD.Results: All tested SNPs genotyped are associated strongly with AMD (p < 0.0001), in concordance with previous studies. However, we found no observable differences in any of the SNPs studied when categorized by sex. Interactions between SNPs and sex were fou..." @default.
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• W2462108915 date "2016-07-15" @default.
• W2462108915 modified "2023-09-26" @default.
• W2462108915 title "No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration" @default.
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• W2462108915 doi "https://doi.org/10.1080/02713683.2016.1196708" @default.
• W2462108915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8324397" @default.
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