FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2462238197> ?p ?o ?g. }

• W2462238197 endingPage "510" @default.
• W2462238197 startingPage "507" @default.
• W2462238197 abstract "Martina, Marco, Caterina Virginio, and Enrico Cherubini. Functionally distinct chloride-mediated GABA responses in rat cerebellar granule cells cultured in a low-potassium medium. J. Neurophysiol. 77: 507–510, 1997. The patch-clamp technique was used to study whole cell currents evoked by γ-aminobutyric acid (GABA) in rat cerebellar granule cells cultured in 5 mM potassium, a condition that favors the development of functionalGABAergic synapses. GABA activated both high- and low-sensitivity receptors. The high-sensitivity receptor had an effective concentration producing half the maximum response (EC 50 ) of 13 μM, whereas the low-sensitivity one had an EC 50 of 255 μM. TheGABA A receptor agonist isoguvacine activated only the high-sensitivity receptor with an EC 50 of 16 μM. When GABA was applied during the desensitized phase of the response elicited by a saturating concentration of isoguvacine, it was still able to induce a small response, whereas when isoguvacine was applied during the desensitizing phase of GABA-evoked current no response was detected. GABA responses were highly heterogeneous regarding their sensitivity to bicuculline. In a small number of cells (3 of 25), bicuculline (10 μM) completely abolished GABA-evoked currents. In the majority of the neurons (22 of 25) the blocking effect of bicuculline (100 μM) was 64 ± 4% (mean ± SE). The bicuculline-resistant component was abolished by picrotoxin (100 μM). In bicuculline, the dose-response curve for GABA was fitted with a sigmoidal curve with an EC 50 value of 209 μM. These data indicate that functional new GABA receptor types with unusual pharmacology could be switched on by conditions that maintain cells in their undifferentiated state." @default.
• W2462238197 created "2016-07-22" @default.
• W2462238197 creator A5027552825 @default.
• W2462238197 creator A5054923894 @default.
• W2462238197 creator A5055139782 @default.
• W2462238197 date "1997-01-01" @default.
• W2462238197 modified "2023-10-03" @default.
• W2462238197 title "Functionally Distinct Chloride-Mediated GABA Responses in Rat Cerebellar Granule Cells Cultured in a Low-Potassium Medium" @default.
• W2462238197 cites W1923025892 @default.
• W2462238197 cites W1989724203 @default.
• W2462238197 cites W1992479059 @default.
• W2462238197 cites W1994288348 @default.
• W2462238197 cites W2013253007 @default.
• W2462238197 cites W2023546249 @default.
• W2462238197 cites W2026559607 @default.
• W2462238197 cites W2060296773 @default.
• W2462238197 cites W2065775311 @default.
• W2462238197 cites W2073046696 @default.
• W2462238197 cites W2086399192 @default.
• W2462238197 cites W2106001183 @default.
• W2462238197 cites W2123307057 @default.
• W2462238197 cites W2410908559 @default.
• W2462238197 cites W2412999044 @default.
• W2462238197 cites W4251535289 @default.
• W2462238197 doi "https://doi.org/10.1152/jn.1997.77.1.507" @default.
• W2462238197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9120592" @default.
• W2462238197 hasPublicationYear "1997" @default.
• W2462238197 type Work @default.
• W2462238197 sameAs 2462238197 @default.
• W2462238197 citedByCount "7" @default.
• W2462238197 crossrefType "journal-article" @default.
• W2462238197 hasAuthorship W2462238197A5027552825 @default.
• W2462238197 hasAuthorship W2462238197A5054923894 @default.
• W2462238197 hasAuthorship W2462238197A5055139782 @default.
• W2462238197 hasConcept C12554922 @default.
• W2462238197 hasConcept C147944092 @default.
• W2462238197 hasConcept C168258287 @default.
• W2462238197 hasConcept C169760540 @default.
• W2462238197 hasConcept C170493617 @default.
• W2462238197 hasConcept C185592680 @default.
• W2462238197 hasConcept C2778938600 @default.
• W2462238197 hasConcept C2779324764 @default.
• W2462238197 hasConcept C2780763569 @default.
• W2462238197 hasConcept C55493867 @default.
• W2462238197 hasConcept C86803240 @default.
• W2462238197 hasConceptScore W2462238197C12554922 @default.
• W2462238197 hasConceptScore W2462238197C147944092 @default.
• W2462238197 hasConceptScore W2462238197C168258287 @default.
• W2462238197 hasConceptScore W2462238197C169760540 @default.
• W2462238197 hasConceptScore W2462238197C170493617 @default.
• W2462238197 hasConceptScore W2462238197C185592680 @default.
• W2462238197 hasConceptScore W2462238197C2778938600 @default.
• W2462238197 hasConceptScore W2462238197C2779324764 @default.
• W2462238197 hasConceptScore W2462238197C2780763569 @default.
• W2462238197 hasConceptScore W2462238197C55493867 @default.
• W2462238197 hasConceptScore W2462238197C86803240 @default.
• W2462238197 hasIssue "1" @default.
• W2462238197 hasLocation W24622381971 @default.
• W2462238197 hasLocation W24622381972 @default.
• W2462238197 hasOpenAccess W2462238197 @default.
• W2462238197 hasPrimaryLocation W24622381971 @default.
• W2462238197 hasRelatedWork W186582574 @default.
• W2462238197 hasRelatedWork W1998242829 @default.
• W2462238197 hasRelatedWork W1999466129 @default.
• W2462238197 hasRelatedWork W2036822324 @default.
• W2462238197 hasRelatedWork W2057167526 @default.
• W2462238197 hasRelatedWork W2109881210 @default.
• W2462238197 hasRelatedWork W2114089489 @default.
• W2462238197 hasRelatedWork W2170692651 @default.
• W2462238197 hasRelatedWork W2343822148 @default.
• W2462238197 hasRelatedWork W2353472698 @default.
• W2462238197 hasVolume "77" @default.
• W2462238197 isParatext "false" @default.
• W2462238197 isRetracted "false" @default.
• W2462238197 magId "2462238197" @default.
• W2462238197 workType "article" @default.