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- W2462281970 abstract "SUMMARY Seventeen adult volunteers werevaccinated orally withthelive attenuated Salmonella typhi mutantstrain Ty21a. Their peripheral bloodmononuclear cells weretested at different timesafter vaccination fordirect cell-mediated activity against bacteria, employing asimple short-term invitro assay. Itwasobserved that16/17 ofthevaccinated subjects acquired thecapacity toexpress specific cellular immunity against S.typhi which lasted from15daystoatleast 3years. Theeffector cell oftheinvitro antibacterial activity waspreliminarily characterized asanon-adherent T3+,T8-,T4+lymphocyte. Inparallel, miceimmunized orally withS.typhimurium andproving resistant toreinfection were tested employing thesameinvitro assay. Alsointhis caseperipheral and, mostimportant, intestinal lymphocytes wereable toexpress cellular immunity against theagent ofmurine typhoid. Itisconcluded that administration oflive oral vaccine against S.typhi results in theinduction ofspecific cellular immunity whichisexpressed attheperipheral and, probably, also attheintestinal level." @default.
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- W2462281970 date "1987-01-01" @default.
- W2462281970 modified "2023-09-27" @default.
- W2462281970 title "Cellular immunity against Salmonella typhi after live oral vaccine." @default.
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