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- W2462378098 abstract "As a continuation of our search for novel anti-inflammatory agents, we examined a series of 9—substituted benzyl-3-substituted carbazole derivatives and discovered that some of these compounds possessed promising activity. Among them, 9-(2-chlorobenzyl)-9H-carbazole-3-carbaaldehyde (3b), 9-(2-chlorobenzyl)-3-hydroxymethylcarbazole (4b) and 9-( 4-chlorobenzyl)-3-hydroxymethylcarbazole (4d) were most potent. Compound 3b inhibited neutrophil degranulation and superoxide anion formation while 4b and 4d selectively inhibited neutrophil degranulation at concentrations (IC50 value 2.0 uM) 6 to 7 times lower than the positive control, trifluoperazine (TFP). These three carbazole compounds are worthy of further exploration for their anti-inflammatory activities." @default.
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- W2462378098 date "2002-02-01" @default.
- W2462378098 modified "2023-09-26" @default.
- W2462378098 title "Anti-inflammatory activity of 9-substituted benzyl-3-substituted carbazole derivatives" @default.
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