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• W2462492575 startingPage "e2147" @default.
• W2462492575 abstract "River buffalo ( Bubalus bubalis ) milk plays an important role in economy and nutritious diet in several developing countries. However, reliable milk-yield genomic markers and their functional insights remain unexposed. Here, we have used a target capture sequencing approach in three economically important buffalo breeds namely: Banni, Jafrabadi and Mehsani , belonging to either high or low milk-yield group. Blood samples were collected from the milk-yield/breed balanced group of 12 buffaloes, and whole exome sequencing was performed using Roche 454 GS-FLX Titanium sequencer. Using an innovative approach namely, MultiCom ; we have identified high-quality SNPs specific for high and low-milk yield buffaloes. Almost 70% of the reported genes in QTL regions of milk-yield and milk-fat in cattle were present among the buffalo milk-yield gene candidates. Functional analysis highlighted transcriptional regulation category in the low milk-yield group, and several new pathways in the two groups. Further, the discovered SNP candidates may account for more than half of mammary transcriptome changes in high versus low-milk yielding cattle. Thus, starting from the design of a reliable strategy, we identified reliable genomic markers specific for high and low-milk yield buffalo breeds and addressed possible downstream effects." @default.
• W2462492575 created "2016-07-22" @default.
• W2462492575 creator A5027977875 @default.
• W2462492575 creator A5058012904 @default.
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• W2462492575 date "2016-07-07" @default.
• W2462492575 modified "2023-10-16" @default.
• W2462492575 title "Comparative analysis of SNP candidates in disparate milk yielding river buffaloes using targeted sequencing" @default.
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• W2462492575 doi "https://doi.org/10.7717/peerj.2147" @default.
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• W2462492575 hasPublicationYear "2016" @default.
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