FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2462541330> ?p ?o ?g. }

• W2462541330 abstract "The effect of 3,3-dichlorobenzidine (DCB), a potent inducer of CYP1A, on the levels of heme oxygenase-1 mRNA and metallothionein mRNAs was examined in the kidney, liver and lung of rats administered a single ip dose (157 μmol/kg) of the compound. DCB treatment increased heme oxygenase-I mRNA abundance in the kidney significantly from barely detectable levels in untreated animals; the maximum increase in the liver and lung was 24-fold and 4-fold, respectively. Hepatic microsomal heme oxygenase activity was also induced by DCB. In contrast with DCB, 2 other P450 inducers, β-naphthoflavone (β-NF) and phenobarbital did not elevate tissue HO-1 rnRNA levels. DCB pretreatment also elevated metallothionein mRNA levels in the kidney, liver and lung, with the effect in the lung being the least pronounced. In contrast with HO-1 mRNA, metallothionein mRNA was increased by the other P450 inducers examined. In vivo lipid peroxidation and in vitro NADPH-dependent microsomal lipid peroxidation were increased in the liver of DCB-treated rats but not in those of phenobarbital- or β-naphthoflavone-treated rats. Treatment with DCB or β-NF did not alter total hepatic microsomal P450 content, as measured spectrophotometrically, but induced the activity of CYP1A2. In contrast, the activity of CYP1A1 was induced to a lesser extent by DCB than by β-NF. The data show that DCB induces HO-1 as weD as P450 1A, confirm stimulation of lipid peroxidation by the compound, and suggest oxidative stress as a mechanism of HO-1 induction by the compound." @default.
• W2462541330 created "2016-07-22" @default.
• W2462541330 creator A5040768148 @default.
• W2462541330 creator A5050077586 @default.
• W2462541330 date "1995-08-01" @default.
• W2462541330 modified "2023-09-23" @default.
• W2462541330 title "Heme oxygenase-1 mRNA levels, metallothionein mRNA levels, lipid peroxidation and microsomal CYP1A activities in rats treated with 3,3-dichlorobenzidine and some other inducers of P450" @default.
• W2462541330 cites W1964648434 @default.
• W2462541330 cites W1966582616 @default.
• W2462541330 cites W1984490307 @default.
• W2462541330 cites W2005528959 @default.
• W2462541330 cites W2007906935 @default.
• W2462541330 cites W2014550587 @default.
• W2462541330 cites W2016196087 @default.
• W2462541330 cites W2021061739 @default.
• W2462541330 cites W2024365580 @default.
• W2462541330 cites W2024983422 @default.
• W2462541330 cites W2028010584 @default.
• W2462541330 cites W2029074995 @default.
• W2462541330 cites W2030050564 @default.
• W2462541330 cites W2041553103 @default.
• W2462541330 cites W2052428509 @default.
• W2462541330 cites W2065101979 @default.
• W2462541330 cites W2065923396 @default.
• W2462541330 cites W2080540331 @default.
• W2462541330 cites W2086671748 @default.
• W2462541330 cites W2087342782 @default.
• W2462541330 cites W2092791929 @default.
• W2462541330 cites W2092983592 @default.
• W2462541330 cites W2118519973 @default.
• W2462541330 cites W2127223050 @default.
• W2462541330 cites W2204618410 @default.
• W2462541330 cites W2277631733 @default.
• W2462541330 cites W2480415555 @default.
• W2462541330 cites W2493775132 @default.
• W2462541330 cites W337608727 @default.
• W2462541330 cites W4294216491 @default.
• W2462541330 doi "https://doi.org/10.1080/13510002.1995.11746998" @default.
• W2462541330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27405715" @default.
• W2462541330 hasPublicationYear "1995" @default.
• W2462541330 type Work @default.
• W2462541330 sameAs 2462541330 @default.
• W2462541330 citedByCount "5" @default.
• W2462541330 crossrefType "journal-article" @default.
• W2462541330 hasAuthorship W2462541330A5040768148 @default.
• W2462541330 hasAuthorship W2462541330A5050077586 @default.
• W2462541330 hasConcept C104317684 @default.
• W2462541330 hasConcept C105580179 @default.
• W2462541330 hasConcept C126322002 @default.
• W2462541330 hasConcept C132154277 @default.
• W2462541330 hasConcept C134018914 @default.
• W2462541330 hasConcept C181199279 @default.
• W2462541330 hasConcept C185592680 @default.
• W2462541330 hasConcept C202751555 @default.
• W2462541330 hasConcept C20719415 @default.
• W2462541330 hasConcept C2225953 @default.
• W2462541330 hasConcept C2776151105 @default.
• W2462541330 hasConcept C2776217839 @default.
• W2462541330 hasConcept C2776524530 @default.
• W2462541330 hasConcept C2779219270 @default.
• W2462541330 hasConcept C2780091579 @default.
• W2462541330 hasConcept C2780829032 @default.
• W2462541330 hasConcept C526171541 @default.
• W2462541330 hasConcept C55493867 @default.
• W2462541330 hasConcept C71924100 @default.
• W2462541330 hasConcept C86803240 @default.
• W2462541330 hasConcept C87644729 @default.
• W2462541330 hasConceptScore W2462541330C104317684 @default.
• W2462541330 hasConceptScore W2462541330C105580179 @default.
• W2462541330 hasConceptScore W2462541330C126322002 @default.
• W2462541330 hasConceptScore W2462541330C132154277 @default.
• W2462541330 hasConceptScore W2462541330C134018914 @default.
• W2462541330 hasConceptScore W2462541330C181199279 @default.
• W2462541330 hasConceptScore W2462541330C185592680 @default.
• W2462541330 hasConceptScore W2462541330C202751555 @default.
• W2462541330 hasConceptScore W2462541330C20719415 @default.
• W2462541330 hasConceptScore W2462541330C2225953 @default.
• W2462541330 hasConceptScore W2462541330C2776151105 @default.
• W2462541330 hasConceptScore W2462541330C2776217839 @default.
• W2462541330 hasConceptScore W2462541330C2776524530 @default.
• W2462541330 hasConceptScore W2462541330C2779219270 @default.
• W2462541330 hasConceptScore W2462541330C2780091579 @default.
• W2462541330 hasConceptScore W2462541330C2780829032 @default.
• W2462541330 hasConceptScore W2462541330C526171541 @default.
• W2462541330 hasConceptScore W2462541330C55493867 @default.
• W2462541330 hasConceptScore W2462541330C71924100 @default.
• W2462541330 hasConceptScore W2462541330C86803240 @default.
• W2462541330 hasConceptScore W2462541330C87644729 @default.
• W2462541330 hasLocation W24625413301 @default.
• W2462541330 hasLocation W24625413302 @default.
• W2462541330 hasOpenAccess W2462541330 @default.
• W2462541330 hasPrimaryLocation W24625413301 @default.
• W2462541330 hasRelatedWork W1507068223 @default.
• W2462541330 hasRelatedWork W1519277389 @default.
• W2462541330 hasRelatedWork W1662332848 @default.
• W2462541330 hasRelatedWork W1963956021 @default.
• W2462541330 hasRelatedWork W1979663143 @default.
• W2462541330 hasRelatedWork W2008759580 @default.
• W2462541330 hasRelatedWork W2025306353 @default.
• W2462541330 hasRelatedWork W2028021793 @default.

• next