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- W2462560219 abstract "Some S-acyl derivatives of N-alkylthiosalicylamides [Table I, II: substances (I leads to XXXIII)] in which the acyl group on S in a carbamic or thiocarbamic N-monosubstituted group were prepared and tested in vitro for antifungal activity. All the substances which are not previously recorded were prepared by condensation of 2-mercapto-N-alkylbenzamides with suitable isocyanates or isothiocyanates. The fungistatic activity of the products prepared was tested in vitro against the two strains: Candida albicans and Trichophyton mentagrophytes. The results (Table I and II) show that the N-monosubstituted S-carbamoyl and S-thiocarbamoyl derivatives of N-monosubstituted amides of thiosalicyclic acid have marked in vitro antimycotic activity. Many derivatives have activity of the same order of magnitude as that of clotrimazole and of these the most active compound is 2-(N-phenylcarbamoylmercapto)-N,n-heptylbenzamide (XXVI)." @default.
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- W2462560219 date "1979-04-01" @default.
- W2462560219 modified "2023-09-23" @default.
- W2462560219 title "[S-acyl derivatives of thiosalicylamides and their anti-fungal activity. IV]." @default.
- W2462560219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/399927" @default.
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