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- W2462653987 abstract "Photodynamic therapy (PDT) is an anti-tumor treatment administered for the elimination of early-stage malignancies and the palliation of symptoms in patients with late-stage tumors, which involves the activation of a photosensitizer (PS) using light of a specific wavelength, which also generates singlet oxygen and other reactive oxygen species (ROS) that cause tumor cell death. Several mechanisms are involved in the protective responses to PDT including the expression of chaperone/heat shock proteins (HSPs). The HSPs are a family of proteins that are induced by cells in response to exposure to stressful conditions. In the last few decades, it has been discovered that HSPs can play an important role in cell survival, due to the fact that they are responsible for many cytoprotective mechanisms. These proteins have different functions depending on their intracellular or extracellular location. In general, intracellular HSPs have been related to an anti-apoptotic function and recently, HSP-induced autophagy has shown to have a protective role in these chaperones. In contrast, extracellular HSPs or membrane-bound HSPs mediate immunological functions. In the present article, we attempt to review the current knowledge concerning the role of HSPs in the outcome of PDT in relation to autophagy and apoptosis mediated-resistance to photodynamic treatment. We will also discuss how certain PDT protocols optimally stimulate the immune system through HSPs." @default.
- W2462653987 created "2016-07-22" @default.
- W2462653987 creator A5043160389 @default.
- W2462653987 creator A5047532806 @default.
- W2462653987 creator A5047550611 @default.
- W2462653987 creator A5052289961 @default.
- W2462653987 creator A5078585135 @default.
- W2462653987 date "2016-09-01" @default.
- W2462653987 modified "2023-10-11" @default.
- W2462653987 title "Heat shock proteins in the context of photodynamic therapy: autophagy, apoptosis and immunogenic cell death" @default.
- W2462653987 cites W1159770521 @default.
- W2462653987 cites W1515506492 @default.
- W2462653987 cites W1543365329 @default.
- W2462653987 cites W1598920916 @default.
- W2462653987 cites W1890354534 @default.
- W2462653987 cites W1916661321 @default.
- W2462653987 cites W1963517711 @default.
- W2462653987 cites W1965943262 @default.
- W2462653987 cites W1966292763 @default.
- W2462653987 cites W1968432606 @default.
- W2462653987 cites W1969468821 @default.
- W2462653987 cites W1972542282 @default.
- W2462653987 cites W1976065095 @default.
- W2462653987 cites W1981765038 @default.
- W2462653987 cites W1982935652 @default.
- W2462653987 cites W1986081651 @default.
- W2462653987 cites W1989908292 @default.
- W2462653987 cites W1991730412 @default.
- W2462653987 cites W1992136500 @default.
- W2462653987 cites W1992354862 @default.
- W2462653987 cites W1993069510 @default.
- W2462653987 cites W1993218631 @default.
- W2462653987 cites W1994924724 @default.
- W2462653987 cites W1997309716 @default.
- W2462653987 cites W1998074678 @default.
- W2462653987 cites W1998192361 @default.
- W2462653987 cites W1998631287 @default.
- W2462653987 cites W2001082819 @default.
- W2462653987 cites W2006894707 @default.
- W2462653987 cites W2008441315 @default.
- W2462653987 cites W2016145333 @default.
- W2462653987 cites W2018636808 @default.
- W2462653987 cites W2021269700 @default.
- W2462653987 cites W2022883845 @default.
- W2462653987 cites W2023338943 @default.
- W2462653987 cites W2024336151 @default.
- W2462653987 cites W2025845392 @default.
- W2462653987 cites W2029690888 @default.
- W2462653987 cites W2034710772 @default.
- W2462653987 cites W2037951366 @default.
- W2462653987 cites W2039346519 @default.
- W2462653987 cites W2041685462 @default.
- W2462653987 cites W2044630250 @default.
- W2462653987 cites W2045843284 @default.
- W2462653987 cites W2046949873 @default.
- W2462653987 cites W2048668585 @default.
- W2462653987 cites W2051758909 @default.
- W2462653987 cites W2052176070 @default.
- W2462653987 cites W2054076973 @default.
- W2462653987 cites W2057063608 @default.
- W2462653987 cites W2057274775 @default.
- W2462653987 cites W2057835131 @default.
- W2462653987 cites W2060902443 @default.
- W2462653987 cites W2067632426 @default.
- W2462653987 cites W2069163264 @default.
- W2462653987 cites W2071563028 @default.
- W2462653987 cites W2072064957 @default.
- W2462653987 cites W2072925339 @default.
- W2462653987 cites W2076718144 @default.
- W2462653987 cites W2078225696 @default.
- W2462653987 cites W2086410486 @default.
- W2462653987 cites W2089400513 @default.
- W2462653987 cites W2089686334 @default.
- W2462653987 cites W2091209638 @default.
- W2462653987 cites W2092923173 @default.
- W2462653987 cites W2095231417 @default.
- W2462653987 cites W2098070947 @default.
- W2462653987 cites W2102389930 @default.
- W2462653987 cites W2109017691 @default.
- W2462653987 cites W2111858669 @default.
- W2462653987 cites W2112050326 @default.
- W2462653987 cites W2112877326 @default.
- W2462653987 cites W2115914766 @default.
- W2462653987 cites W2119421712 @default.
- W2462653987 cites W2120426523 @default.
- W2462653987 cites W2122216968 @default.
- W2462653987 cites W2123469465 @default.
- W2462653987 cites W2130789168 @default.
- W2462653987 cites W2133288737 @default.
- W2462653987 cites W2134428662 @default.
- W2462653987 cites W2137690550 @default.
- W2462653987 cites W2145567565 @default.
- W2462653987 cites W2146961420 @default.
- W2462653987 cites W2148396143 @default.
- W2462653987 cites W2150123812 @default.
- W2462653987 cites W2150378018 @default.
- W2462653987 cites W2151734986 @default.
- W2462653987 cites W2157013283 @default.