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- W2462663314 abstract "To analyse the epidemiological feature, clinical characters and therapeutic regimens for von Willebrand disease(VWD).The clinical data and laboratory tests results of 162 VWD patients in our center were analyzed.There were 76 males and 86 female among these patients with the mean age of 7.2(2.0-41.0) and 20.7(5.0-48.0) years, respectively. 86 patients (53.1%) were identified to be type 1 VWD, 34 patients (21.0%) type 3 VWD and 42 patients (25.9%) type 2 VWD. Among type 2 VWD patients, 33 patients were type 2A, 4 patients type 2M, 5 patients type 2B. Eighty-seven patients (53.7%) had a definite family history of bleeding tendency. The most common and specific bleeding symptoms were easy bruising (61.7%), epistaxis (53.7%), prolonged bleeding after surgery or minor injury (53.1%). Menorrhagia (66.3%) was common in female patients. The analysis of Vicenza bleeding scores in all patients showed that only 56(34.6%) patients had abnormal bleeding scores. FVIII/VWF concentrates and cryoprecipitate were applied to 45 patients (27.8% ), Desmopressin (DDAVP) to 8 patients. Eight female patients need oral contraceptives jointly to control menorrhagia. Hysterectomy had to be performed in 2 female patients with VWD.VWD was a common congenital bleeding disorder with heterogeneous characters, it was necessary to screen, identify, classify accurately this disease in order to supply to effectively individualized treatment." @default.
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- W2462663314 date "2014-02-01" @default.
- W2462663314 modified "2023-09-26" @default.
- W2462663314 title "[Clinical studies of 162 patients with von Willebrand disease]." @default.
- W2462663314 doi "https://doi.org/10.3760/cma.j.issn.0253-2727.2014.02.020" @default.
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