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- W2462669029 abstract "Abstract New lantibiotic cinnamycin B was isolated from the extract of Actinomadura atramentaria NBRC 14695T, based on genome mining and chemical investigation. The partial structure of cinnamycin B was established by 2D NMR experiments, which indicated that cinnamycin B had same methyl lanthionine bridging pattern with cinnamycin. The reduction with NaBH4-NiCl2 afforded the reduced cinnamycin B, and MS/MS experiment indicated the presence of hydroxy asparatic acid in the molecule. Cinnamycin B showed an antibacterial activity against Streptomyces antibioticus with dosage of 5 μg (0.5μL, 10 mg/mL solution) at spot-on-lawn testing method. The gene cluster of cinnamycin B on the genome of A. atramentaria was identified and discussed in comparison with that of cinnamycin." @default.
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- W2462669029 date "2016-08-01" @default.
- W2462669029 modified "2023-09-23" @default.
- W2462669029 title "Isolation and structure determination of a new lantibiotic cinnamycin B from <i>Actinomadura atramentaria</i> based on genome mining" @default.
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- W2462669029 doi "https://doi.org/10.1007/s10295-016-1788-9" @default.
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