Matches in SemOpenAlex for { <https://semopenalex.org/work/W2462675595> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2462675595 abstract "In this post hoc analysis of the EDGE study, we assessed the effectiveness and safety of vildagliptin versus other oral antidiabetes drugs (OADs) as add-on to first-line sulphonylurea (SU) therapy in patients who did not receive metformin in a real-life setting.The primary endpoint was odds of achieving an HbA1c reduction of >0.3% without tolerability issues. Secondary endpoint was odds of achieving HbA1c <7.0% without hypoglycaemia or weight gain. Changes in HbA1c, body weight; and safety were also assessed.2936 patients received vildagliptin and 820 received comparator OADs (any α-GI, TZD, glinide) as add-on to first-line SU therapy. Overall, the mean age, disease duration, HbA1c, and BMI at baseline were 57.1 years, 6.3 years, 8.5%, and 27.7kg/m2, respectively. The odds ratios for achieving primary and secondary endpoints were 1.6 (95% CI: 1.36, 1.86; p<0.0001) and 1.8 (1.45, 2.21; p<0.0001), respectively, in favour of vildagliptin. The between-treatment differences (vildagliptin vs. comparator OAD) for the mean change in HbA1c and body weight were -0.2±0.04% (p<0.0001) and -0.8±0.16kg (p<0.0001), respectively. Overall, the incidence of adverse events was low (vildagliptin, 7% vs. comparator, 8.2%) in both groups. Similar results were observed in a subset of patients enrolled from India and patients who received TZDs as a comparator OAD.Under real-life settings, vildagliptin as add-on to SU monotherapy showed better glycaemic response without tolerability issues compared with other OADs." @default.
- W2462675595 created "2016-07-22" @default.
- W2462675595 creator A5012223517 @default.
- W2462675595 creator A5018280114 @default.
- W2462675595 creator A5018289692 @default.
- W2462675595 creator A5037570427 @default.
- W2462675595 creator A5043986676 @default.
- W2462675595 creator A5053469409 @default.
- W2462675595 date "2016-12-01" @default.
- W2462675595 modified "2023-10-03" @default.
- W2462675595 title "Effectiveness of vildagliptin versus other oral antidiabetes drugs as add-on to sulphonylurea monotherapy: Post hoc analysis from the EDGE study" @default.
- W2462675595 cites W1728748816 @default.
- W2462675595 cites W1805640194 @default.
- W2462675595 cites W1977595596 @default.
- W2462675595 cites W1982311681 @default.
- W2462675595 cites W1994832750 @default.
- W2462675595 cites W2003221950 @default.
- W2462675595 cites W2008677894 @default.
- W2462675595 cites W2023984564 @default.
- W2462675595 cites W2045970464 @default.
- W2462675595 cites W2060083804 @default.
- W2462675595 cites W2071652229 @default.
- W2462675595 cites W2097112828 @default.
- W2462675595 cites W2105407506 @default.
- W2462675595 cites W2138206806 @default.
- W2462675595 cites W2156990409 @default.
- W2462675595 cites W2160088494 @default.
- W2462675595 doi "https://doi.org/10.1016/j.pcd.2016.06.001" @default.
- W2462675595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27353459" @default.
- W2462675595 hasPublicationYear "2016" @default.
- W2462675595 type Work @default.
- W2462675595 sameAs 2462675595 @default.
- W2462675595 citedByCount "0" @default.
- W2462675595 crossrefType "journal-article" @default.
- W2462675595 hasAuthorship W2462675595A5012223517 @default.
- W2462675595 hasAuthorship W2462675595A5018280114 @default.
- W2462675595 hasAuthorship W2462675595A5018289692 @default.
- W2462675595 hasAuthorship W2462675595A5037570427 @default.
- W2462675595 hasAuthorship W2462675595A5043986676 @default.
- W2462675595 hasAuthorship W2462675595A5053469409 @default.
- W2462675595 hasBestOaLocation W24626755951 @default.
- W2462675595 hasConcept C126322002 @default.
- W2462675595 hasConcept C134018914 @default.
- W2462675595 hasConcept C156957248 @default.
- W2462675595 hasConcept C168563851 @default.
- W2462675595 hasConcept C197934379 @default.
- W2462675595 hasConcept C203092338 @default.
- W2462675595 hasConcept C2776453732 @default.
- W2462675595 hasConcept C2777180221 @default.
- W2462675595 hasConcept C2778375690 @default.
- W2462675595 hasConcept C2780323712 @default.
- W2462675595 hasConcept C555293320 @default.
- W2462675595 hasConcept C67761136 @default.
- W2462675595 hasConcept C71924100 @default.
- W2462675595 hasConcept C90924648 @default.
- W2462675595 hasConceptScore W2462675595C126322002 @default.
- W2462675595 hasConceptScore W2462675595C134018914 @default.
- W2462675595 hasConceptScore W2462675595C156957248 @default.
- W2462675595 hasConceptScore W2462675595C168563851 @default.
- W2462675595 hasConceptScore W2462675595C197934379 @default.
- W2462675595 hasConceptScore W2462675595C203092338 @default.
- W2462675595 hasConceptScore W2462675595C2776453732 @default.
- W2462675595 hasConceptScore W2462675595C2777180221 @default.
- W2462675595 hasConceptScore W2462675595C2778375690 @default.
- W2462675595 hasConceptScore W2462675595C2780323712 @default.
- W2462675595 hasConceptScore W2462675595C555293320 @default.
- W2462675595 hasConceptScore W2462675595C67761136 @default.
- W2462675595 hasConceptScore W2462675595C71924100 @default.
- W2462675595 hasConceptScore W2462675595C90924648 @default.
- W2462675595 hasLocation W24626755951 @default.
- W2462675595 hasLocation W24626755952 @default.
- W2462675595 hasLocation W24626755953 @default.
- W2462675595 hasOpenAccess W2462675595 @default.
- W2462675595 hasPrimaryLocation W24626755951 @default.
- W2462675595 hasRelatedWork W2099305220 @default.
- W2462675595 hasRelatedWork W2115408777 @default.
- W2462675595 hasRelatedWork W2117762041 @default.
- W2462675595 hasRelatedWork W2124465362 @default.
- W2462675595 hasRelatedWork W2173506240 @default.
- W2462675595 hasRelatedWork W2462675595 @default.
- W2462675595 hasRelatedWork W3003411222 @default.
- W2462675595 hasRelatedWork W3135879765 @default.
- W2462675595 hasRelatedWork W4205719544 @default.
- W2462675595 hasRelatedWork W4220781513 @default.
- W2462675595 isParatext "false" @default.
- W2462675595 isRetracted "false" @default.
- W2462675595 magId "2462675595" @default.
- W2462675595 workType "article" @default.