FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2462785530> ?p ?o ?g. }

• W2462785530 endingPage "724" @default.
• W2462785530 startingPage "714" @default.
• W2462785530 abstract "Macrophage-derived foam cells are important constituents of atheromatous lesions. In addition to the scavenger receptor pathway, uptake of immune complexed lipoproteins through IgG Fc receptors (Fc gamma receptors) represents an additional pathway of macrophage foam cell development that may be important during atherogenesis. The importance of this mechanism is suggested by studies showing that the titer of autoantibodies to modified lipoproteins correlated with the extent of occlusive disease in patients, and that those antibodies exist in human lesions. Human mononuclear phagocytes possess three structurally and functionally distinct classes of Fc gamma receptors, each of which could be associated with a unique pathway of lipoprotein metabolism. In order to determine whether uptake of an acute lipid load through each type of Fc gamma receptor was associated with foam cell development, we used bispecific antibodies consisting of anti-LDL monoclonal antibodies conjugated to anti-Fc gamma receptor monoclonal antibodies to study the effects of targeting LDL aggregates to each specific type of Fc gamma receptor on freshly isolated adherent human monocytes. Relative to appropriate controls, LDL degradation, cellular sterol mass, and foam cell development of monocytes were enhanced by targeting LDL aggregates to Fc gamma RI or Fc gamma RII, and this was accompanied by an apparent impairment of LDL degradation. Uptake was specific to the Fc gamma receptors and was not influenced by the presence of scavenger receptor ligands. Thus, with the bispecific approach, the functions of each class of Fc gamma receptor can be studied on an individual basis with respect to several aspects of cellular cholesterol metabolism. This will be critical for determining which of these receptors are potentially most important in the clearance of lipoprotein immune complexes during atherogenesis." @default.
• W2462785530 created "2016-07-22" @default.
• W2462785530 creator A5020207188 @default.
• W2462785530 creator A5060431241 @default.
• W2462785530 creator A5081914657 @default.
• W2462785530 creator A5091694808 @default.
• W2462785530 date "1995-04-01" @default.
• W2462785530 modified "2023-09-26" @default.
• W2462785530 title "Enhanced metabolism of LDL aggregates mediated by specific human monocyte IgG Fc receptors." @default.
• W2462785530 cites W1522459970 @default.
• W2462785530 cites W1968038750 @default.
• W2462785530 cites W1968567802 @default.
• W2462785530 cites W1969853805 @default.
• W2462785530 cites W1991726504 @default.
• W2462785530 cites W1994164919 @default.
• W2462785530 cites W2009811622 @default.
• W2462785530 cites W2015553762 @default.
• W2462785530 cites W2041483436 @default.
• W2462785530 cites W2042667997 @default.
• W2462785530 cites W2045022813 @default.
• W2462785530 cites W2050496310 @default.
• W2462785530 cites W2050874860 @default.
• W2462785530 cites W2064570494 @default.
• W2462785530 cites W2066466775 @default.
• W2462785530 cites W2084429561 @default.
• W2462785530 cites W2091943511 @default.
• W2462785530 cites W2094810303 @default.
• W2462785530 cites W2096938610 @default.
• W2462785530 cites W2102131116 @default.
• W2462785530 cites W2111232004 @default.
• W2462785530 cites W2115001977 @default.
• W2462785530 cites W2120626817 @default.
• W2462785530 cites W2120651556 @default.
• W2462785530 cites W2126204744 @default.
• W2462785530 cites W2134579258 @default.
• W2462785530 cites W2159506419 @default.
• W2462785530 cites W2162458714 @default.
• W2462785530 cites W2181756237 @default.
• W2462785530 cites W2184891169 @default.
• W2462785530 cites W2188707394 @default.
• W2462785530 cites W2189476938 @default.
• W2462785530 cites W4211053163 @default.
• W2462785530 doi "https://doi.org/10.1016/s0022-2275(20)40057-4" @default.
• W2462785530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7616118" @default.
• W2462785530 hasPublicationYear "1995" @default.
• W2462785530 type Work @default.
• W2462785530 sameAs 2462785530 @default.
• W2462785530 citedByCount "29" @default.
• W2462785530 countsByYear W24627855302012 @default.
• W2462785530 countsByYear W24627855302022 @default.
• W2462785530 crossrefType "journal-article" @default.
• W2462785530 hasAuthorship W2462785530A5020207188 @default.
• W2462785530 hasAuthorship W2462785530A5060431241 @default.
• W2462785530 hasAuthorship W2462785530A5081914657 @default.
• W2462785530 hasAuthorship W2462785530A5091694808 @default.
• W2462785530 hasBestOaLocation W24627855301 @default.
• W2462785530 hasConcept C159654299 @default.
• W2462785530 hasConcept C170493617 @default.
• W2462785530 hasConcept C185592680 @default.
• W2462785530 hasConcept C203014093 @default.
• W2462785530 hasConcept C2778163477 @default.
• W2462785530 hasConcept C2779931124 @default.
• W2462785530 hasConcept C2780072125 @default.
• W2462785530 hasConcept C2780898057 @default.
• W2462785530 hasConcept C2781184567 @default.
• W2462785530 hasConcept C2909900342 @default.
• W2462785530 hasConcept C43554185 @default.
• W2462785530 hasConcept C55493867 @default.
• W2462785530 hasConcept C62231903 @default.
• W2462785530 hasConcept C86803240 @default.
• W2462785530 hasConceptScore W2462785530C159654299 @default.
• W2462785530 hasConceptScore W2462785530C170493617 @default.
• W2462785530 hasConceptScore W2462785530C185592680 @default.
• W2462785530 hasConceptScore W2462785530C203014093 @default.
• W2462785530 hasConceptScore W2462785530C2778163477 @default.
• W2462785530 hasConceptScore W2462785530C2779931124 @default.
• W2462785530 hasConceptScore W2462785530C2780072125 @default.
• W2462785530 hasConceptScore W2462785530C2780898057 @default.
• W2462785530 hasConceptScore W2462785530C2781184567 @default.
• W2462785530 hasConceptScore W2462785530C2909900342 @default.
• W2462785530 hasConceptScore W2462785530C43554185 @default.
• W2462785530 hasConceptScore W2462785530C55493867 @default.
• W2462785530 hasConceptScore W2462785530C62231903 @default.
• W2462785530 hasConceptScore W2462785530C86803240 @default.
• W2462785530 hasIssue "4" @default.
• W2462785530 hasLocation W24627855301 @default.
• W2462785530 hasOpenAccess W2462785530 @default.
• W2462785530 hasPrimaryLocation W24627855301 @default.
• W2462785530 hasRelatedWork W1532403879 @default.
• W2462785530 hasRelatedWork W1955828664 @default.
• W2462785530 hasRelatedWork W1975082171 @default.
• W2462785530 hasRelatedWork W1997894801 @default.
• W2462785530 hasRelatedWork W2044283553 @default.
• W2462785530 hasRelatedWork W205101329 @default.
• W2462785530 hasRelatedWork W2061641422 @default.
• W2462785530 hasRelatedWork W2132566750 @default.
• W2462785530 hasRelatedWork W2967565826 @default.
• W2462785530 hasRelatedWork W4313310208 @default.

• next