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- W2462901811 abstract "During the gestation and the lactating periods the gustatory papillae contain taste buds that respond to different flavors and aversive stimuli. The current study analyzed the effects of pre-and neonatal undernutrition on the circumvallate papillae of rats at 12, 20, and 30days of age. Early undernourishment occurred from gestational days G6 to G19 when dams received low percentages of food followed by a balanced diet from G20-21. After birth pups were underfed by rotating two lactating dams every 12h; in one of them, the nipples were tied. The pups were weaned at 25days of age, and then given an ad libitum diet. Under anesthesia the tongues were removed and stained with the hematoxylin-eosin (H-E) procedure. The results indicated that young underfed rats had significantly body weight reductions. The tongue measurements in underfed rats showed reduced total area and length of the anterior portion, but there were negligible effects on the posterior portion. The circumvallate papillae in underfed rats was significantly reduced in major length, major diameter, and total and upper areas, but unaffected in the lateral wall trench region. The taste bud areas and minor diameter were unaffected by undernutrition, but there were significant reductions in the total number of visible taste buds and the major diameter, delayed opening of taste bud pores, and an increased number of closed pores were also observed. These alterations by undernutrition reflect the vulnerability of structures in the gustatory oral cavity and suggest a possible interference with the receptorś activation, and transduction and perhaps with the taste encoding of signals to generate the gustatory sensory and hedonic responses." @default.
- W2462901811 created "2016-07-22" @default.
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- W2462901811 date "2016-07-01" @default.
- W2462901811 modified "2023-10-14" @default.
- W2462901811 title "Effects of perinatal undernutrition on the circumvallate papilla of developing Wistar rats" @default.
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- W2462901811 doi "https://doi.org/10.1016/j.acthis.2016.06.003" @default.
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