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• W2463013896 endingPage "556" @default.
• W2463013896 startingPage "550" @default.
• W2463013896 abstract "During meiosis, exchange of DNA segments occurs between paired homologous chromosomes in order to produce recombinant chromosomes, helping to increase genetic diversity within a species. This genetic exchange process is tightly controlled by the eukaryotic RecA homologs Rad51 and Dmc1, which are involved in strand exchange of meiotic recombination, with Rad51 participating specifically in mitotic recombination. Meiotic recombination requires an interaction between homologous chromosomes to repair programmed double-strand breaks (DSBs). In this study, we investigated the budding yeast meiosis-specific proteins Hop2 and Sae3, which function in the Dmc1-dependent pathway. This pathway mediates the homology searching and strand invasion processes. Mek1 kinase participates in switching meiotic recombination from sister bias to homolog bias after DSB formation. In the absence of Hop2 and Sae3, DSBs were produced normally, but showed defects in the DSB-to-single-end invasion transition mediated by Dmc1 and auxiliary factors, and mutant strains failed to complete proper chromosome segregation. However, in the absence of Mek1 kinase activity, Rad51-dependent recombination progressed via sister bias in the hop2Δ or sae3Δ mutants, even in the presence of Dmc1. Thus, Hop2 and Sae3 actively modulate Dmc1-dependent recombination, effectively progressing homolog bias, a process requiring Mek1 kinase activation." @default.
• W2463013896 created "2016-07-22" @default.
• W2463013896 creator A5024049281 @default.
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• W2463013896 creator A5067357361 @default.
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• W2463013896 date "2016-06-21" @default.
• W2463013896 modified "2023-10-14" @default.
• W2463013896 title "Hop2 and Sae3 Are Required for Dmc1-Mediated Double-Strand Break Repair via Homolog Bias during Meiosis" @default.
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• W2463013896 doi "https://doi.org/10.14348/molcells.2016.0069" @default.
• W2463013896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4959020" @default.
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• W2463013896 hasPublicationYear "2016" @default.
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