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- W2463022494 abstract "Dehydroepiandrosterone (DHEA, 2) is an important endogenous steroid hormone in mammals used in the treatment of a variety of dysfunctions in female and male health,1 as well as an intermediate in the synthesis of steroidal drugs, such as abiraterone acetate which is used for the treatment of prostate cancer.2−4 In this manuscript we describe a novel, concise, and cost-efficient route toward DHEA (2) and DHEA acetate (3) from 4-androstene-3,17-dione (4-AD, 1). Crucial to success was the identification of a ketoreductase from Sphingomonas wittichii for the highly regio- and stereoselective reduction of the C3-carbonyl group of 5-androstene-3,17-dione (5) to the required 3β-alcohol (2, >99% de). The enzyme displayed excellent robustness and solvent stability under high substrate concentrations (up to 150 g/L)." @default.
- W2463022494 created "2016-07-22" @default.
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- W2463022494 date "2016-07-20" @default.
- W2463022494 modified "2023-10-14" @default.
- W2463022494 title "Development of a Chemoenzymatic Process for Dehydroepiandrosterone Acetate Synthesis" @default.
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- W2463022494 doi "https://doi.org/10.1021/acs.oprd.6b00215" @default.
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