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- W2463156765 abstract "The interferon regulatory factor (IRF) family comprises nine members in both humans and mice. These proteins were first identified as transcriptional regulators of type I interferons (IFNs) and IFN-inducible genes, and they have been implicated in the regulation of immune responses and immune cell development. Recently, studies indicate that IRFs are attractive targets not only for treating infectious and autoimmune diseases but also for treating cardiometabolic diseases due to their immune-dependent and immune-independent actions. In this review, we summarize the current knowledge of the biological functions of IRFs in immune responses and immune cell development and highlight our contemporary understanding of the molecular mechanisms of IRFs in the cardiometabolic systems that participate in the pathogenesis of cardiometabolic diseases, including metabolic diseases, cardiac remodeling, vascular remodeling, and stroke. A complete understanding of the functions of IRFs in cardiometabolic systems might contribute our ability to manage the initiation and progression of cardiometabolic disorders." @default.
- W2463156765 created "2016-07-22" @default.
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- W2463156765 date "1969-12-31" @default.
- W2463156765 modified "2023-09-24" @default.
- W2463156765 title "Targeting Interferon Regulatory Factors in Cardiometabolic Diseases" @default.
- W2463156765 hasPublicationYear "1969" @default.
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