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• W2463301499 abstract "Introduction: A combination of granulocyte colony-stimulating factor (G-CSF) and chemotherapy or G-CSF alone are the most common mobilization regimens for autotransplantations. Plerixafor is used for mobilization of CD34+ cells with G-CSF in non-Hodgkin lymphoma (NHL) and myeloma (MM) patients.Areas covered: The available phase II and III data on plerixafor has been reviewed. The efficacy of plerixafor in the mobilization of CD34+ cells in predicted poor mobilizers as well as in patients who had failed a mobilization has been evaluated. The pre-emptive use of plerixafor as well as studies on cost-effectiveness are covered. Also effects in the composition of the collected grafts along with the data on long-term outcome of plerixafor-mobilized patients is discussed.Expert commentary: Plerixafor combined with G-CSF mobilizes CD34+ cells more efficiently than G-CSF alone in patients with NHL or MM. In phase III studies, engraftment after high-dose therapy has been comparable to G-CSF mobilized patients. The pre-emptive use of plerixafor added to mobilization with chemotherapy plus G-CSF or with G-CSF alone has gained more popularity. This approach may be more cost-effective than the routine use of this drug. The changes observed in the composition of grafts after plerixafor injection may have implications for post-transplant events." @default.
• W2463301499 created "2016-07-22" @default.
• W2463301499 creator A5018038225 @default.
• W2463301499 creator A5078430570 @default.
• W2463301499 creator A5078478211 @default.
• W2463301499 date "2016-07-15" @default.
• W2463301499 modified "2023-09-24" @default.
• W2463301499 title "Plerixafor injection: a hematopoietic stem cell mobilizer in non-Hodgkin lymphoma and multiple myeloma" @default.
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• W2463301499 doi "https://doi.org/10.1080/17474086.2016.1208082" @default.
• W2463301499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27355397" @default.
• W2463301499 hasPublicationYear "2016" @default.
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