Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463332011> ?p ?o ?g. }
- W2463332011 abstract "Mental health disorders(MHD) in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have been widely studied. However, the underlying role of inflammatory cytokines and their associated signaling pathways have not been investigated. Here, we report the potential role of cytokines and associated signaling pathways in CP/CPPS patients with MHD and in a CP/CPPS animal model. CP/CPPS patients (n = 810) and control subjects (n = 992) were enrolled in this case-control multicenter study, and serum cytokine levels were measured. Male Sprague-Dawley rats received multiple intracutaneous injections of an immuno-agent along with a pertussis-diphtheria-tetanus triple vaccine for autoimmune CP/CPPS development. The results revealed that, in CP/CPPS patients with significant MHD, elevated IL-1α, IL-1β, IL-4, IL-13, and TNF-α serum levels were observed. The above five cytokines in CP/CPPS rats were significantly elevated in prostate tissue (p < 0.05), and IL-1β levels were elevated in serum and cerebrospinal fluid. In behavioral tests, CP/CPPS rats showed anxiety- and depression-like symptoms, and impaired spatial and associative memory performance (p < 0.05). In the CP/CPPS group, ERK1/2 phosphorylation levels were increased in the amygdala and nucleus accumbens, and decreased in the hippocampus, but not caudate nucleus. Thus, prostate-derived cytokines, especially IL-1β, cross the blood brain barrier and may lead to enhanced ERK1/2 signaling in several brain areas, possibly underlying induction of CP/CPPS-related MHD." @default.
- W2463332011 created "2016-07-22" @default.
- W2463332011 creator A5003797990 @default.
- W2463332011 creator A5013671823 @default.
- W2463332011 creator A5025168493 @default.
- W2463332011 creator A5031366364 @default.
- W2463332011 creator A5046249005 @default.
- W2463332011 creator A5053756140 @default.
- W2463332011 creator A5056465234 @default.
- W2463332011 creator A5071368242 @default.
- W2463332011 creator A5077161823 @default.
- W2463332011 creator A5081961473 @default.
- W2463332011 creator A5088640959 @default.
- W2463332011 creator A5091637974 @default.
- W2463332011 date "2016-06-01" @default.
- W2463332011 modified "2023-09-25" @default.
- W2463332011 title "The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders" @default.
- W2463332011 cites W1776845629 @default.
- W2463332011 cites W1883938883 @default.
- W2463332011 cites W1969202258 @default.
- W2463332011 cites W1970879944 @default.
- W2463332011 cites W1981003034 @default.
- W2463332011 cites W1984609303 @default.
- W2463332011 cites W1989206354 @default.
- W2463332011 cites W1997517088 @default.
- W2463332011 cites W2000545031 @default.
- W2463332011 cites W2007043862 @default.
- W2463332011 cites W2010555262 @default.
- W2463332011 cites W2010699231 @default.
- W2463332011 cites W2015592781 @default.
- W2463332011 cites W2016678016 @default.
- W2463332011 cites W202598497 @default.
- W2463332011 cites W2025997841 @default.
- W2463332011 cites W2030040169 @default.
- W2463332011 cites W2031438074 @default.
- W2463332011 cites W2033817719 @default.
- W2463332011 cites W2034503042 @default.
- W2463332011 cites W2037093360 @default.
- W2463332011 cites W2042415483 @default.
- W2463332011 cites W2043765825 @default.
- W2463332011 cites W2050180989 @default.
- W2463332011 cites W2051874402 @default.
- W2463332011 cites W2051920122 @default.
- W2463332011 cites W2060035717 @default.
- W2463332011 cites W2061186744 @default.
- W2463332011 cites W2064851328 @default.
- W2463332011 cites W2066427182 @default.
- W2463332011 cites W2070031257 @default.
- W2463332011 cites W2070447896 @default.
- W2463332011 cites W2073957455 @default.
- W2463332011 cites W2080628209 @default.
- W2463332011 cites W2082848310 @default.
- W2463332011 cites W2088751222 @default.
- W2463332011 cites W2090883291 @default.
- W2463332011 cites W2091364814 @default.
- W2463332011 cites W2095822659 @default.
- W2463332011 cites W2096611698 @default.
- W2463332011 cites W2101626807 @default.
- W2463332011 cites W2114827666 @default.
- W2463332011 cites W2118252411 @default.
- W2463332011 cites W2118977349 @default.
- W2463332011 cites W2119290671 @default.
- W2463332011 cites W2119883892 @default.
- W2463332011 cites W2121672362 @default.
- W2463332011 cites W2122062108 @default.
- W2463332011 cites W2141059794 @default.
- W2463332011 cites W2143863807 @default.
- W2463332011 cites W2146247985 @default.
- W2463332011 cites W2147833502 @default.
- W2463332011 cites W2149861820 @default.
- W2463332011 cites W2163269381 @default.
- W2463332011 cites W2166158223 @default.
- W2463332011 cites W2167415113 @default.
- W2463332011 cites W2168221314 @default.
- W2463332011 cites W2170298556 @default.
- W2463332011 cites W342856410 @default.
- W2463332011 doi "https://doi.org/10.1038/srep28608" @default.
- W2463332011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4917855" @default.
- W2463332011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27334333" @default.
- W2463332011 hasPublicationYear "2016" @default.
- W2463332011 type Work @default.
- W2463332011 sameAs 2463332011 @default.
- W2463332011 citedByCount "35" @default.
- W2463332011 countsByYear W24633320112017 @default.
- W2463332011 countsByYear W24633320112018 @default.
- W2463332011 countsByYear W24633320112019 @default.
- W2463332011 countsByYear W24633320112020 @default.
- W2463332011 countsByYear W24633320112021 @default.
- W2463332011 countsByYear W24633320112022 @default.
- W2463332011 countsByYear W24633320112023 @default.
- W2463332011 crossrefType "journal-article" @default.
- W2463332011 hasAuthorship W2463332011A5003797990 @default.
- W2463332011 hasAuthorship W2463332011A5013671823 @default.
- W2463332011 hasAuthorship W2463332011A5025168493 @default.
- W2463332011 hasAuthorship W2463332011A5031366364 @default.
- W2463332011 hasAuthorship W2463332011A5046249005 @default.
- W2463332011 hasAuthorship W2463332011A5053756140 @default.
- W2463332011 hasAuthorship W2463332011A5056465234 @default.
- W2463332011 hasAuthorship W2463332011A5071368242 @default.
- W2463332011 hasAuthorship W2463332011A5077161823 @default.