Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463362625> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2463362625 endingPage "81" @default.
- W2463362625 startingPage "178" @default.
- W2463362625 abstract "To examine the effect of cinobufacini on rat thoracic aorta and its mechanism.Isolated rat thoracic aorta was perfused and isometric tension was recorded by organ bath technique before and after cinobufacini treatment.Cinobufacini induced contraction of isolated thoracic aorta with or without endothelium in a concentration-dependent manner (at concentration of 2.5,5.0,7.5,10.0 g/L). The vasoconstriction effect of cinobufacini was more potent in endothelium-denuded aorta ring [(16.3+/-3.39)%, (52.5+/-7.70)%, (60.9+/-8.84)%, (69.2+/-11.34)%] than in endothelium-intact aorta ring [(6.2+/-2.07)%, (14.7+/-4.91), (17.6+/-5.86)%, (20.3+/-6.78)% (P<0.01)]. Its contractile effect was attenuated in Ca(2+)-free solution (about 1/10 of that in buffer with 1.25 mmol/L CaCl(2)) or by the treatment with verapamil (10(-7)mol/L), an L-type calcium channel antagonist. Cinobufacini induced contraction on the endothelium-intact rat aorta was augmented by pretreatment with L-NAME (10(-4)mol/L), a nitric oxide synthase inhibitor.Cinobufacini contracts rat thoracic aorta by opening the voltage-dependent Ca(2+) channel and increasing Ca(2+) influx into vascular smooth muscle. Cinobufacini can also stimulate the release of vascular relaxant factor, nitric oxide, from the endothelium and thus antagonize cinobufacini-induced contraction." @default.
- W2463362625 created "2016-07-22" @default.
- W2463362625 creator A5039801376 @default.
- W2463362625 creator A5044607592 @default.
- W2463362625 creator A5050051337 @default.
- W2463362625 creator A5059633880 @default.
- W2463362625 date "2006-03-01" @default.
- W2463362625 modified "2023-09-23" @default.
- W2463362625 title "[Effect of cinobufacini on vascular contractile of rat thoracic aorta]." @default.
- W2463362625 doi "https://doi.org/10.3785/j.issn.1008-9292.2006.02.012" @default.
- W2463362625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16610085" @default.
- W2463362625 hasPublicationYear "2006" @default.
- W2463362625 type Work @default.
- W2463362625 sameAs 2463362625 @default.
- W2463362625 citedByCount "1" @default.
- W2463362625 countsByYear W24633626252020 @default.
- W2463362625 crossrefType "journal-article" @default.
- W2463362625 hasAuthorship W2463362625A5039801376 @default.
- W2463362625 hasAuthorship W2463362625A5044607592 @default.
- W2463362625 hasAuthorship W2463362625A5050051337 @default.
- W2463362625 hasAuthorship W2463362625A5059633880 @default.
- W2463362625 hasConcept C103486182 @default.
- W2463362625 hasConcept C105702510 @default.
- W2463362625 hasConcept C126322002 @default.
- W2463362625 hasConcept C134018914 @default.
- W2463362625 hasConcept C163415756 @default.
- W2463362625 hasConcept C185592680 @default.
- W2463362625 hasConcept C2776864027 @default.
- W2463362625 hasConcept C2776992346 @default.
- W2463362625 hasConcept C2777022698 @default.
- W2463362625 hasConcept C2777622882 @default.
- W2463362625 hasConcept C2779395532 @default.
- W2463362625 hasConcept C2779961880 @default.
- W2463362625 hasConcept C2779980429 @default.
- W2463362625 hasConcept C2992686903 @default.
- W2463362625 hasConcept C519063684 @default.
- W2463362625 hasConcept C519581460 @default.
- W2463362625 hasConcept C71924100 @default.
- W2463362625 hasConceptScore W2463362625C103486182 @default.
- W2463362625 hasConceptScore W2463362625C105702510 @default.
- W2463362625 hasConceptScore W2463362625C126322002 @default.
- W2463362625 hasConceptScore W2463362625C134018914 @default.
- W2463362625 hasConceptScore W2463362625C163415756 @default.
- W2463362625 hasConceptScore W2463362625C185592680 @default.
- W2463362625 hasConceptScore W2463362625C2776864027 @default.
- W2463362625 hasConceptScore W2463362625C2776992346 @default.
- W2463362625 hasConceptScore W2463362625C2777022698 @default.
- W2463362625 hasConceptScore W2463362625C2777622882 @default.
- W2463362625 hasConceptScore W2463362625C2779395532 @default.
- W2463362625 hasConceptScore W2463362625C2779961880 @default.
- W2463362625 hasConceptScore W2463362625C2779980429 @default.
- W2463362625 hasConceptScore W2463362625C2992686903 @default.
- W2463362625 hasConceptScore W2463362625C519063684 @default.
- W2463362625 hasConceptScore W2463362625C519581460 @default.
- W2463362625 hasConceptScore W2463362625C71924100 @default.
- W2463362625 hasIssue "2" @default.
- W2463362625 hasLocation W24633626251 @default.
- W2463362625 hasOpenAccess W2463362625 @default.
- W2463362625 hasPrimaryLocation W24633626251 @default.
- W2463362625 hasRelatedWork W1969008342 @default.
- W2463362625 hasRelatedWork W2003131541 @default.
- W2463362625 hasRelatedWork W2004954535 @default.
- W2463362625 hasRelatedWork W2012185701 @default.
- W2463362625 hasRelatedWork W2019267286 @default.
- W2463362625 hasRelatedWork W2026851380 @default.
- W2463362625 hasRelatedWork W2043076116 @default.
- W2463362625 hasRelatedWork W2051560932 @default.
- W2463362625 hasRelatedWork W2053152946 @default.
- W2463362625 hasRelatedWork W2054589098 @default.
- W2463362625 hasRelatedWork W2056578174 @default.
- W2463362625 hasRelatedWork W2074159955 @default.
- W2463362625 hasRelatedWork W2324844491 @default.
- W2463362625 hasRelatedWork W2326417371 @default.
- W2463362625 hasRelatedWork W2330280266 @default.
- W2463362625 hasRelatedWork W2358642625 @default.
- W2463362625 hasRelatedWork W2387360771 @default.
- W2463362625 hasRelatedWork W2387865079 @default.
- W2463362625 hasRelatedWork W2410021364 @default.
- W2463362625 hasRelatedWork W2415712206 @default.
- W2463362625 hasVolume "35" @default.
- W2463362625 isParatext "false" @default.
- W2463362625 isRetracted "false" @default.
- W2463362625 magId "2463362625" @default.
- W2463362625 workType "article" @default.