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- W2463365232 abstract "Studies on the survival of histocompatibility-Y antigen (H-Y)-incompatible and skin-specific antigen (Skn)-incom- patible skin grafts in mice, as well as those concerned with the survival of cultured parathyroid allografts in rats, indicate that grafts provoke a strong immune response only if they include do- nor macrophages (or Langerhans cells) or if major histocompati- bility complex-compatible macrophages are available to react with cells bearing the foreign antigens. Although a major histocompatibility complex (MHC) restriction with respect to transplantation antigens has been amply and repeatedly demonstrated in vitro (1-7), there is no direct evi- dence that it plays a role in sensitizing hosts to skin and other organ allografts in vivo (but see refs. 8-10). We provide evi- dence for such a role. We propose that for a graft to provoke a strong immune response, it is essential that some of its trans- plantation antigens be expressed on donor macrophages (or cells of this family) or be presented to the host by macrophages which are MHC-compatible with the graft. Our support for this proposition originates from a series of seemingly unrelated experiments: some concerned with the behavior of skin grafts incompatible with respect to male-spe- cific histocompatibility-Y (H-Y) or skin-specific (Skn) antigens in mice, and others concerned with the behavior of cultured endocrine allografts in rats. The details of the rat experiment are being published elsewhere (11), and most of the data con- cerning H-Y-incompatible grafts originate from a previous study (12). Thus, although what follows will include data from all of these studies, only the experiments involving Skn will be de- scribed in detail." @default.
- W2463365232 created "2016-07-22" @default.
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- W2463365232 date "2016-01-01" @default.
- W2463365232 modified "2023-09-27" @default.
- W2463365232 title "Evidence for major histocompatibil transplantation immunity (skin-specific antigens/histocompatibility-Y antigen/parathyroid trans" @default.
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- W2463365232 hasPublicationYear "2016" @default.
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