FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463371736> ?p ?o ?g. }

• W2463371736 endingPage "442" @default.
• W2463371736 startingPage "432" @default.
• W2463371736 abstract "This two-sequence, three-period crossover study is the first pharmacokinetic (PK) study to compare all three innovator formulations of tacrolimus (twice-daily immediate-release tacrolimus capsules [IR-Tac]; once-daily extended-release tacrolimus capsules [ER-Tac]; novel once-daily tacrolimus tablets [LCPT]). Stable renal transplant patients were dosed with each drug for 7 days, and blood samples were obtained over 24 h. Thirty subjects were included in the PK analysis set. A conversion factor of 1:1:0.80 for IR-Tac:ER-Tac:LCPT was used; no dose adjustments were permitted during the study. The median (interquartile range) total daily dose was 6.0 (4.0-8.0) mg for IR-Tac and ER-Tac and 4.8 (3.3-6.3) for LCPT. Significantly higher exposure on a per milligram basis, lower intraday fluctuation and prolonged time (Tmax ) to peak concentration (Cmax ) were found for LCPT versus IR-Tac or ER-Tac. ER-Tac showed no differences versus IR-Tac in exposure, Cmax , Tmax or fluctuation. The observed exposure of IR-Tac was used to normalize exposure for LCPT and ER-Tac, resulting in the following recommended total daily dose conversion rates: IR-Tac:ER-Tac, +8%; IR-Tac:LCPT, -30%; ER-Tac:LCPT, -36%. After exposure normalization, Cmax was ~17% lower for LCPT than for IR-Tac or ER-Tac; Cmin was ~6% lower for LCPT compared with IR-Tac and 3% higher compared with ER-Tac." @default.
• W2463371736 created "2016-07-22" @default.
• W2463371736 creator A5006876478 @default.
• W2463371736 creator A5027751857 @default.
• W2463371736 creator A5037987356 @default.
• W2463371736 creator A5061648194 @default.
• W2463371736 creator A5083095696 @default.
• W2463371736 date "2016-08-02" @default.
• W2463371736 modified "2023-09-29" @default.
• W2463371736 title "A Steady-State Head-to-Head Pharmacokinetic Comparison of All FK-506 (Tacrolimus) Formulations (ASTCOFF): An Open-Label, Prospective, Randomized, Two-Arm, Three-Period Crossover Study" @default.
• W2463371736 cites W1480151031 @default.
• W2463371736 cites W1582395273 @default.
• W2463371736 cites W1599829994 @default.
• W2463371736 cites W1929309318 @default.
• W2463371736 cites W1962251849 @default.
• W2463371736 cites W1966201922 @default.
• W2463371736 cites W1983369934 @default.
• W2463371736 cites W1999400963 @default.
• W2463371736 cites W2003143162 @default.
• W2463371736 cites W2010365552 @default.
• W2463371736 cites W2015365405 @default.
• W2463371736 cites W2022748829 @default.
• W2463371736 cites W2031440204 @default.
• W2463371736 cites W2035635857 @default.
• W2463371736 cites W2058180202 @default.
• W2463371736 cites W2058532329 @default.
• W2463371736 cites W2073742622 @default.
• W2463371736 cites W2073742890 @default.
• W2463371736 cites W2076798861 @default.
• W2463371736 cites W2078939327 @default.
• W2463371736 cites W2079263137 @default.
• W2463371736 cites W2089557861 @default.
• W2463371736 cites W2109363195 @default.
• W2463371736 cites W2122406380 @default.
• W2463371736 cites W2131345312 @default.
• W2463371736 cites W2180163584 @default.
• W2463371736 cites W2232930881 @default.
• W2463371736 cites W2319410352 @default.
• W2463371736 cites W2463371736 @default.
• W2463371736 cites W4231346389 @default.
• W2463371736 doi "https://doi.org/10.1111/ajt.13935" @default.
• W2463371736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5297985" @default.
• W2463371736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27340950" @default.
• W2463371736 hasPublicationYear "2016" @default.
• W2463371736 type Work @default.
• W2463371736 sameAs 2463371736 @default.
• W2463371736 citedByCount "97" @default.
• W2463371736 countsByYear W24633717362015 @default.
• W2463371736 countsByYear W24633717362016 @default.
• W2463371736 countsByYear W24633717362017 @default.
• W2463371736 countsByYear W24633717362018 @default.
• W2463371736 countsByYear W24633717362019 @default.
• W2463371736 countsByYear W24633717362020 @default.
• W2463371736 countsByYear W24633717362021 @default.
• W2463371736 countsByYear W24633717362022 @default.
• W2463371736 countsByYear W24633717362023 @default.
• W2463371736 crossrefType "journal-article" @default.
• W2463371736 hasAuthorship W2463371736A5006876478 @default.
• W2463371736 hasAuthorship W2463371736A5027751857 @default.
• W2463371736 hasAuthorship W2463371736A5037987356 @default.
• W2463371736 hasAuthorship W2463371736A5061648194 @default.
• W2463371736 hasAuthorship W2463371736A5083095696 @default.
• W2463371736 hasBestOaLocation W24633717361 @default.
• W2463371736 hasConcept C112705442 @default.
• W2463371736 hasConcept C119060515 @default.
• W2463371736 hasConcept C126322002 @default.
• W2463371736 hasConcept C126894567 @default.
• W2463371736 hasConcept C142724271 @default.
• W2463371736 hasConcept C204787440 @default.
• W2463371736 hasConcept C22979827 @default.
• W2463371736 hasConcept C27081682 @default.
• W2463371736 hasConcept C2778335254 @default.
• W2463371736 hasConcept C2909675724 @default.
• W2463371736 hasConcept C2911091166 @default.
• W2463371736 hasConcept C71924100 @default.
• W2463371736 hasConcept C87813604 @default.
• W2463371736 hasConcept C98274493 @default.
• W2463371736 hasConceptScore W2463371736C112705442 @default.
• W2463371736 hasConceptScore W2463371736C119060515 @default.
• W2463371736 hasConceptScore W2463371736C126322002 @default.
• W2463371736 hasConceptScore W2463371736C126894567 @default.
• W2463371736 hasConceptScore W2463371736C142724271 @default.
• W2463371736 hasConceptScore W2463371736C204787440 @default.
• W2463371736 hasConceptScore W2463371736C22979827 @default.
• W2463371736 hasConceptScore W2463371736C27081682 @default.
• W2463371736 hasConceptScore W2463371736C2778335254 @default.
• W2463371736 hasConceptScore W2463371736C2909675724 @default.
• W2463371736 hasConceptScore W2463371736C2911091166 @default.
• W2463371736 hasConceptScore W2463371736C71924100 @default.
• W2463371736 hasConceptScore W2463371736C87813604 @default.
• W2463371736 hasConceptScore W2463371736C98274493 @default.
• W2463371736 hasFunder F4320315650 @default.
• W2463371736 hasIssue "2" @default.
• W2463371736 hasLocation W24633717361 @default.
• W2463371736 hasLocation W24633717362 @default.
• W2463371736 hasLocation W24633717363 @default.
• W2463371736 hasLocation W24633717364 @default.
• W2463371736 hasOpenAccess W2463371736 @default.

• next