FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2463387400> ?p ?o ?g. }

• W2463387400 endingPage "1852" @default.
• W2463387400 startingPage "1841" @default.
• W2463387400 abstract "Childhood maltreatment (CM) has been associated with altered brain morphology, which may partly be due to a direct impact on neural growth, e.g. through the brain-derived neurotrophic factor (BDNF) pathway. Findings on CM, BDNF and brain volume are inconsistent and have never accounted for the entire BDNF pathway. We examined the effects of CM, BDNF (genotype, gene expression and protein level) and their interactions on hippocampus, amygdala and anterior cingulate cortex (ACC) morphology. Data were collected from patients with depression and/or an anxiety disorder and healthy subjects within the Netherlands Study of Depression and Anxiety (NESDA) ( N = 289). CM was assessed using the Childhood Trauma Interview. BDNF Val66Met genotype, gene expression and serum protein levels were determined in blood and T1 MRI scans were acquired at 3T. Regional brain morphology was assessed using FreeSurfer. Covariate-adjusted linear regression analyses were performed. Amygdala volume was lower in maltreated individuals. This was more pronounced in maltreated met-allele carriers. The expected positive relationship between BDNF gene expression and volume of the amygdala is attenuated in maltreated subjects. Finally, decreased cortical thickness of the ACC was identified in maltreated subjects with the val/val genotype. CM was associated with altered brain morphology, partly in interaction with multiple levels of the BNDF pathway. Our results suggest that CM has different effects on brain morphology in met-carriers and val-homozygotes and that CM may disrupt the neuroprotective effect of BDNF." @default.
• W2463387400 created "2016-07-22" @default.
• W2463387400 creator A5006025400 @default.
• W2463387400 creator A5008602701 @default.
• W2463387400 creator A5030054670 @default.
• W2463387400 creator A5038822755 @default.
• W2463387400 creator A5044982581 @default.
• W2463387400 creator A5051193242 @default.
• W2463387400 creator A5055183685 @default.
• W2463387400 creator A5078303098 @default.
• W2463387400 creator A5084976375 @default.
• W2463387400 date "2016-07-12" @default.
• W2463387400 modified "2023-10-16" @default.
• W2463387400 title "Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology" @default.
• W2463387400 cites W1500442275 @default.
• W2463387400 cites W1520184724 @default.
• W2463387400 cites W1907802063 @default.
• W2463387400 cites W1967100996 @default.
• W2463387400 cites W1971063595 @default.
• W2463387400 cites W1971367443 @default.
• W2463387400 cites W1977419693 @default.
• W2463387400 cites W1981674307 @default.
• W2463387400 cites W1985856579 @default.
• W2463387400 cites W1987029965 @default.
• W2463387400 cites W1996251825 @default.
• W2463387400 cites W1999128166 @default.
• W2463387400 cites W2000209446 @default.
• W2463387400 cites W2003641508 @default.
• W2463387400 cites W2007156391 @default.
• W2463387400 cites W2008113854 @default.
• W2463387400 cites W2013010572 @default.
• W2463387400 cites W2013373204 @default.
• W2463387400 cites W2015851283 @default.
• W2463387400 cites W2024992929 @default.
• W2463387400 cites W2030868131 @default.
• W2463387400 cites W2031156721 @default.
• W2463387400 cites W2037383099 @default.
• W2463387400 cites W2039047987 @default.
• W2463387400 cites W2039792137 @default.
• W2463387400 cites W2040546819 @default.
• W2463387400 cites W2043103881 @default.
• W2463387400 cites W2045940397 @default.
• W2463387400 cites W2050618347 @default.
• W2463387400 cites W2056306621 @default.
• W2463387400 cites W2061196406 @default.
• W2463387400 cites W2064212981 @default.
• W2463387400 cites W2073884643 @default.
• W2463387400 cites W2075627129 @default.
• W2463387400 cites W2077313724 @default.
• W2463387400 cites W2079348783 @default.
• W2463387400 cites W2080377907 @default.
• W2463387400 cites W2083312379 @default.
• W2463387400 cites W2084207424 @default.
• W2463387400 cites W2087761877 @default.
• W2463387400 cites W2091308413 @default.
• W2463387400 cites W2093354456 @default.
• W2463387400 cites W2093694233 @default.
• W2463387400 cites W2096550964 @default.
• W2463387400 cites W2099280287 @default.
• W2463387400 cites W2106030064 @default.
• W2463387400 cites W2107724071 @default.
• W2463387400 cites W2110747672 @default.
• W2463387400 cites W2111078070 @default.
• W2463387400 cites W2111477880 @default.
• W2463387400 cites W2112262501 @default.
• W2463387400 cites W2113282160 @default.
• W2463387400 cites W2114879270 @default.
• W2463387400 cites W2116584334 @default.
• W2463387400 cites W2117830068 @default.
• W2463387400 cites W2121247237 @default.
• W2463387400 cites W2124084192 @default.
• W2463387400 cites W2127857741 @default.
• W2463387400 cites W2128152843 @default.
• W2463387400 cites W2130417276 @default.
• W2463387400 cites W2134144143 @default.
• W2463387400 cites W2136403062 @default.
• W2463387400 cites W2139407404 @default.
• W2463387400 cites W2139565721 @default.
• W2463387400 cites W2145516237 @default.
• W2463387400 cites W2151775239 @default.
• W2463387400 cites W2156993271 @default.
• W2463387400 cites W2159772210 @default.
• W2463387400 cites W2164147534 @default.
• W2463387400 cites W2168921497 @default.
• W2463387400 cites W2170990401 @default.
• W2463387400 doi "https://doi.org/10.1093/scan/nsw086" @default.
• W2463387400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5091678" @default.
• W2463387400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27405617" @default.
• W2463387400 hasPublicationYear "2016" @default.
• W2463387400 type Work @default.
• W2463387400 sameAs 2463387400 @default.
• W2463387400 citedByCount "42" @default.
• W2463387400 countsByYear W24633874002017 @default.
• W2463387400 countsByYear W24633874002018 @default.
• W2463387400 countsByYear W24633874002019 @default.
• W2463387400 countsByYear W24633874002020 @default.
• W2463387400 countsByYear W24633874002021 @default.
• W2463387400 countsByYear W24633874002022 @default.

• next